Posenacaftor sodium - ≥99% , CAS No.2095064-06-3

CAS: 2095064-06-3 Cat. No.: P651963 Peso molecular: 467.49 PubChem CID: 135350953

GRADE & PURITY ≥99%

Synonyms

PTI-801 (sodium) | SCHEMBL20526947 | Posenacaftor (sodium) | 4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-((1R)-1-(tetrahydro-2H-pyran-4-yl)ethoxy)-, sodium salt (1:1) | DJC89RV1GS | PTI-801 sodium | 2095064-06-3 | Posenacaftor sodiu

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF).

In Vitro

Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells.Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells. Posenacaftor is a CFTR corrector, correctors are always designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinónimos

PTI-801 (sodium) | SCHEMBL20526947 | Posenacaftor (sodium) | 4-Quinolinecarboxylic acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-((1R)-1-(tetrahydro-2H-pyran-4-yl)ethoxy)-, sodium salt (1:1) | DJC89RV1GS | PTI-801 sodium | 2095064-06-3 | Posenacaftor sodiu

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking ofxa0CFTRxa0protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF).

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CC1=C2C(=C(C=C1)OC(C)C3CCOCC3)C(=CC(=N2)C4=C(C5=CC=CC=C5O4)C)C(=O)[O-].[Na+]
• IUPAC Name: sodium;8-methyl-2-(3-methyl-1-benzofuran-2-yl)-5-[(1R)-1-(oxan-4-yl)ethoxy]quinoline-4-carboxylate
• InChIKey: FIMNRWQYZVDFTK-UNTBIKODSA-M
• INCHI: 1S/C27H27NO5.Na/c1-15-8-9-23(32-17(3)18-10-12-31-13-11-18)24-20(27(29)30)14-21(28-25(15)24)26-16(2)19-6-4-5-7-22(19)33-26;/h4-9,14,17-18H,10-13H2,1-3H3,(H,29,30);/q;+1/p-1/t17-;/m1./s1
• Isómeros SMILES: CC1=C2C(=C(C=C1)O[C@H](C)C3CCOCC3)C(=CC(=N2)C4=C(C5=CC=CC=C5O4)C)C(=O)[O-].[Na+]
• CAS alternativo: 2095064-06-3
• PubChem CID: 135350953
• Peso molecular: 467.49

Propiedades químicas y físicas

• Solubilidad: DMSO : 200 mg/mL (427.82 mM; Need ultrasonic)