PQ-10 - 10mM in DMSO , CAS No.927691-21-2

CAS: 927691-21-2 Cat. No.: P656713 Peso molecular: 403.43 PubChem CID: 11704101

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia

In Vivo

PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 24 –28 g male C57BL/6 mice, PDE10A WT and KO mice Dosage: 0.16, 0.63, 2.5, and 10 mg/kg Administration: s.c. Result: Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice.

IC50& Target:PDE10A 4.6 nM (IC 50 )

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for res

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)N3CCC(C3)OC4=NC5=CC=CC=C5N=C4)OC
• WGK Alemania: 3
• PubChem CID: 11704101
• Peso molecular: 403.43

Referencias

1. Aoyang Sha, Huifang Yang, Zhengyan He, Zhigao Xu, Chenjie Wu, Wu Ming, Ru'an Chi.  (2023)  Enhancement of weathered crust elution-deposited rare earth ores leaching process with the addition of PQ-10.  JOURNAL OF RARE EARTHS,      [PMID:] [10.1016/j.jre.2023.12.005]

2. Zhaojie Yang, Minghua Zhang, Yafei Xiao, Xi Zhang, Minmin Fan.  (2020)  Facile Fabrication of Poly(vinyl alcohol)/Polyquaternium-10 (PVA/PQ-10) Anion Exchange Membrane with Semi-Interpenetrating Network.  MACROMOLECULAR MATERIALS AND ENGINEERING,  306  (1): (2000506).  [PMID:] [10.1002/mame.202000506]