Prednisolone (NSC-9900) - 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.50-24-8, Glucocorticoid receptor agonist

CAS: 50-24-8 Cat. No.: P409095 Peso molecular: 360.44 Número EC: 200-021-7

GRADE & PURITY 10mM in DMSO

Synonyms

(11β)​-11,​17,​21-​trihydroxy-pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Prednisolone (NSC-9900) Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
In vitro

Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. Prednisolone\'s anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice.

In vivo

Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

(11β)​-11, ​17, ​21-​trihydroxy-pregna-​1, ​4-​diene-​3, ​20-​dione

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

AGONIST

Mecanismo de acción

Glucocorticoid receptor agonist

Propiedades del producto

• ALogP: 1.6

Nombres e identificadores

• Isómeros SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O
• Peso molecular: 360.44
• Reaxy-Rn: 2339782
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339782&ln=

Objetivos asociados (humanos)

NR3C1 Tclin Glucocorticoid receptor (90 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C2 Tclin Mineralocorticoid receptor (8 Activities)

Discover Target: NR3C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SERPINA6 Tchem Corticosteroid-binding globulin (1 Activities)

Discover Target: SERPINA6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAM17 Tchem Disintegrin and metalloproteinase domain-containing protein 17 (1 Activities)

Discover Target: ADAM17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLUL Tchem Glutamine synthetase (1 Activities)

Discover Target: GLUL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL6 Tclin Interleukin-6 (1 Activities)

Discover Target: IL6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de inflamación (°C): 2℃
• Punto de ebullición (°C): 412.46°C (rough estimate)
• Punto de fusión (°C): 240 °C (dec.)(lit.)

Referencias

1. Jiadi Shen, Chenyu Weng, Shuxian Zhu, Wanjing Chen, Xuening Xiong, Xin Wei.  (2025)  Protein Phosphatases 2A Affects Drug Resistance of Candida albicans Biofilm Via ATG Protein Phosphorylation Induction.  INTERNATIONAL DENTAL JOURNAL,      [PMID:40885126] [10.1016/j.identj.2025.103873]

2. Jiadi Shen, Yuzhi Li, Haochen Miao.  (2025)  The PP2A Catalytic Subunit PPH21 Regulates Biofilm Formation and Drug Resistance of Candida albicans.  Microorganisms,  13  (9): (2093).  [PMID:41011426] [10.3390/microorganisms13092093]

3. Guozheng Zhao.  (2023)  Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor.  MOLECULES,  28  (18): (6619).  [PMID:37764395] [10.3390/molecules28186619]

4. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv.  (2023)  Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects.  CHEMISTRY & BIODIVERSITY,      [PMID:38129310] [10.1002/cbdv.202301525]

5. Yunjia Wang, Zhongjing Jiang, Linhua Deng, Gengming Zhang, Xia Xu, Emmanuel Alonge, Hongqi Zhang, Chaofeng Guo.  (2023)  Dendrobium offificinale polysaccharides prevents glucocorticoids-induced osteoporosis by destabilizing KEAP1-NRF2 interaction.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37652317] [10.1016/j.ijbiomac.2023.126600]

6. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang.  (2023)  Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks.  TALANTA,      [PMID:37126925] [10.1016/j.talanta.2023.124589]

7. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen.  (2023)  Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application.  FOOD CHEMISTRY,      [PMID:37116443] [10.1016/j.foodchem.2023.136196]

8. Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li.  (2023)  Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:36996741] [10.1016/j.intimp.2023.110079]

9. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing.  (2022)  Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity.  AAPS PHARMSCITECH,  23  (7): (1-13).  [PMID:36207561] [10.1208/s12249-022-02427-1]

10. Yi Tao, Lin Chen, Meiling Pan, Fei Zhu, Jizhong Yan.  (2021)  Tracing anti-osteoporosis components from raw and salt-processed semen of Cuscuta chinensis by employing a biochemometrics strategy that integrates ultrasonic-assisted extraction, quantitation, efficacy assessment in zebrafish, and grey relationship analysis.  JOURNAL OF SEPARATION SCIENCE,  44  (17): (3229-3236).  [PMID:34240804] [10.1002/jssc.202100272]

11. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li.  (2020)  Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:32173426] [10.1016/j.jep.2020.112764]

12. Shoubao Wang, Yao Xiong, Yinmin Wang, Jingting Chen, Jun Yang, Binbin Sun.  (2020)  Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study.  TRANSPLANT INTERNATIONAL,  33  (4): (450-461).  [PMID:31930539] [10.1111/tri.13574]

13. Jia-Bi Lin, Hao Wu, Yu-Ling Liu, Pang-Chui Shaw, Pei-Bo Li.  (2018)  Transcriptome analysis reveals functional roles of nacreous protein N16 in prednisolone-induced osteoporotic zebrafish.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:30219513] [10.1016/j.ijbiomac.2018.09.055]

14. Guozheng Zhao.  (2024)  Detection of six glucocorticoids using a nanogold-glucocorticoid receptor-based biosensor.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2024.141611]

15. Guowen Li, Mengjia Chao, Chun Zhang, Hang Gao, Xiuping Li, Hongxin Ren, Xinlin Wei, Chifang Peng, Wei Ma, Zhouping Wang.  (2025)  Supraparticle Nanoarchitectonics with Bright Gold Nanoclusters Induced by Host–Guest Recognition for Volatile Amine and Meat Freshness Detection.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.5c00366]

16. Rong Huang, Wenyu Zhang, Yueqi Hu, Junjie Xu, Zhihui Dong, Jikai Liu, Li Zhou.  (2025)  Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40393586] [10.1016/j.ijbiomac.2025.144264]

17. Yuan-Yuan Yang, Bao-Zhu Jia, Zhen-Lin Xu, Yi-Xian Liu, Lin Luo.  (2025)  Magnetic Particle-Based Automated Chemiluminescence Immunoassay for the Determination of Hydrocortisone Residues in Milk.  Foods,  14  (12): (2105).  [PMID:40565714] [10.3390/foods14122105]

18. Xiaolu Chen, Muyao Cui, Jiaqi Li, Qi Chen, Linzhen Chen, Zhuo Yang, Qiqi Fan, Yuhan Sheng, Ruichao Lin, Zhiqiang Ma, Chongjun Zhao.  (2025)  Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models.  Frontiers in Immunology,      [PMID:41394814] [10.3389/fimmu.2025.1722777]

19. Jiang Cheng, Naihui Hou, Tengda Wang, Zhenyun Zhao\u003Csup\u003E*\u003C\u002Fsup\u003E, Wei Chen\u003Csup\u003E*\u003C\u002Fsup\u003E.  (2026)  Dual-function core-shell nanocube probes enabling continuous production of cortisol-sensing yarns via conjugate electrospinning.  Soft Science,  6  (2): (N).  [PMID:] [10.20517/ss.2025.123]