Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca 2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

In Vivo

Procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinónimos

Especificaciones y pureza

Moligand™, ≥99%

Mecanismos bioquímicos y fisiológicos

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Pureza

≥99%

Nombres e identificadores

Sonrisas canónicas	C1C(C(OC2=C1C(=CC3=C2C4C(C(O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)O
IUPAC Name	(1R,5R,6S,13S,21R)-5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.02,11.03,8.015,20]henicosa-2(11),3(8),9,15,17,19-hexaene-6,9,17,19,21-pentol
InChIKey	NSEWTSAADLNHNH-TXZJYACMSA-N
INCHI	1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26+,27+,29+,30-/m0/s1
Isómeros SMILES	C1[C@@H]([C@H](OC2=C1C(=CC3=C2[C@@H]4[C@H]([C@](O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)O
CAS alternativo	103883-03-0
PubChem CID	9872976
Términos de entrada MeSH	proanthocyanidin A-1;proanthocyanidin A1
Peso molecular	576.50

Documentation

📋 Safety Data Sheet (SDS)

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Clase Flavonoids
    - Subclass Biflavonoids and polyflavonoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Clase	Flavonoids
Subclass	Biflavonoids and polyflavonoids
Intermediate Tree Nodes	Not available
Direct Parent	Biflavonoids and polyflavonoids
Alternative Parents	A-type proanthocyanidins Catechins Pyranoflavonoids 3'-hydroxyflavonoids 3-hydroxyflavonoids 4'-hydroxyflavonoids 5-hydroxyflavonoids 7-hydroxyflavonoids Pyranochromenes Catechols 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Ketals Alkyl aryl ethers Benzene and substituted derivatives Secondary alcohols Oxacyclic compounds Polyols Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	A-type proanthocyanidin - Bi- and polyflavonoid skeleton - Proanthocyanidin - Catechin - Pyranoflavonoid - Flavan-3-ol - Hydroxyflavonoid - 3'-hydroxyflavonoid - 7-hydroxyflavonoid - 5-hydroxyflavonoid - 4'-hydroxyflavonoid - 3-hydroxyflavonoid - Flavan - Pyranochromene - Chromane - 1-benzopyran - Benzopyran - Catechol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Ketal - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Polyol - Acetal - Organoheterocyclic compound - Oxacycle - Ether - Hydrocarbon derivative - Alcohol - Organic oxygen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as biflavonoids and polyflavonoids. These are organic compounds containing at least two flavan/flavone units. These units are usually linked through CC or C-O-C bonds. Some examples include C2-O-C3, C2-O-C4, C3'-C3''', and C6-C8''.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

PGF Tclin Placenta growth factor (1 Activities)

Discover Target: PGF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VEGFA Tclin Vascular endothelial growth factor A (1 Activities)

Discover Target: VEGFA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VEGFA Tclin Vascular endothelial growth factor A (159 Activities)

Discover Target: VEGFA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Lot Number	Certificate Type	Fecha	Articulo
C2506638	Certificate of Analysis	Feb 28, 2025	P640226
C2506639	Certificate of Analysis	Feb 28, 2025	P640226
C2506641	Certificate of Analysis	Feb 28, 2025	P640226
C2506642	Certificate of Analysis	Feb 28, 2025	P640226
C2506643	Certificate of Analysis	Feb 28, 2025	P640226
C2506649	Certificate of Analysis	Feb 28, 2025	P640226
C2506650	Certificate of Analysis	Feb 28, 2025	P640226
C2506652	Certificate of Analysis	Feb 28, 2025	P640226
C2506653	Certificate of Analysis	Feb 28, 2025	P640226

Solubilidad	DMSO : 100 mg/mL (173.46 mM; Need ultrasonic)
Sensibilidad	Light sensitive
Peso molecular	576.500 g/mol
XLogP3	2.400
Hydrogen Bond Donor Count	9
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	2
Exact Mass	576.127 Da
Monoisotopic Mass	576.127 Da
Topological Polar Surface Area	210.000 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	986.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Procyanidin A1 - Moligand™, ≥99% , CAS No.103883-03-0

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Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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