Prodipine hydrochloride - ≥99% , CAS No.31314-39-3

CAS: 31314-39-3 Cat. No.: P651099 Peso molecular: 315.9 PubChem CID: 3030531

GRADE & PURITY ≥99%

Synonyms

AKOS040740874 | Prodipine hydrochloride [MI] | 1-Isopropyl-4,4-diphenylpiperidine hydrochloride | MS-24646 | SCHEMBL11739494 | NIOSH/TM7755000 | Prodipine hydrochloride | HY-101605 | 89CCP8Z2PS | Piperidine, 4,4-diphenyl-1-isopropyl-, hydrochloride | BY-1

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Prodipine, a diphenyl-phosphonate derivative. The IC 50 s of Prodipine for purified and plasma Dipeptidyl peptidase IV ( DPP IV ) from the rabbit are 4.5 μM and 30 μM, respectively.

In Vitro

Prodipine, a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC 50 values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remaines unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV)

Specifications

Sinónimos

AKOS040740874 | Prodipine hydrochloride [MI] | 1-Isopropyl-4, 4-diphenylpiperidine hydrochloride | MS-24646 | SCHEMBL11739494 | NIOSH/TM7755000 | Prodipine hydrochloride | HY-101605 | 89CCP8Z2PS | Piperidine, 4, 4-diphenyl-1-isopropyl-, hydrochloride | BY-1

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Prodipine, a diphenyl-phosphonate derivative. The IC 50 s of Prodipine for purified and plasma Dipeptidyl peptidase IV ( DPP IV ) from the rabbit are 4.5 μM and 30 μM, respectively.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CC(C)N1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3.Cl
• IUPAC Name: 4,4-diphenyl-1-propan-2-ylpiperidine;hydrochloride
• InChIKey: ZFCBOUXJVGNRIF-UHFFFAOYSA-N
• INCHI: 1S/C20H25N.ClH/c1-17(2)21-15-13-20(14-16-21,18-9-5-3-6-10-18)19-11-7-4-8-12-19;/h3-12,17H,13-16H2,1-2H3;1H
• Isómeros SMILES: CC(C)N1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3.Cl
• PubChem CID: 3030531
• Peso molecular: 315.9

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Phenylpiperidines Aralkylamines Trialkylamines Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diphenylmethane - Phenylpiperidine - Aralkylamine - Piperidine - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Peso molecular: 315.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 315.175 Da
• Monoisotopic Mass: 315.175 Da
• Topological Polar Surface Area: 3.200 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 282.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3