Prostaglandin E₁ - γ-irradiated, BioReagent, for cell culture, powder, γ-irradiated, BioXtra, suitable for cell culture , CAS No.745-65-3

CAS: 745-65-3 Cat. No.: P755633 Peso molecular: 354.48 Beilstein Registry Number: 5294062 Número EC: 212-017-2

GRADE & PURITY BioReagent, for Cell culture, γ-irradiated, powder, γ-irradiated, BioXtra, suitable for cell culture

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.

Prostaglandin E1 has been used in maintaining mice proximal tubule, and NRK-52E, a rat renal epithelial cell line.

Specifications

Especificaciones y pureza

γ-irradiated, BioReagent, for cell culture, powder, γ-irradiated, BioXtra, suitable for cell culture

Mecanismos bioquímicos y fisiológicos

Prostaglandins mediate vasodilation and vasoconstriction, the E series of prostaglandin is a highly effective vasodilator. It is known to efficiently cause erythema. Prostaglandin E1 is considered as a potent pyretic factor, and acts through cerebral vent

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

BioReagent, for Cell culture, γ-irradiated

Propiedades del producto

• ALogP: 3.2

Nombres e identificadores

• Sonrisas canónicas: CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
• IUPAC Name: 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
• InChIKey: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• INCHI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• Isómeros SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O
• WGK Alemania: 3
• RTECS: GY4569800
• Número ONU: 2811
• Grupo de embalaje: III
• Peso molecular: 354.48
• Beilstein: 5294062
• Reaxy-Rn: 2704847
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2704847&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Prostaglandins and related compounds
• Alternative Parents: Long-chain fatty acids Fatty alcohols Hydroxy fatty acids Cyclopentanols Cyclic ketones Cyclic alcohols and derivatives Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Prostaglandin skeleton - Long-chain fatty acid - Fatty alcohol - Hydroxy fatty acid - Cyclopentanol - Cyclic alcohol - Cyclic ketone - Ketone - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Alcohol - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Organooxygen compound - Aliphatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.
• External Descriptors: Prostaglandins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: ethanol: 1 mg/mL
• Punto de ebullición (°C): 529.28 °C/760 mmHg
• Punto de fusión (°C): 114-115°C
• Peso molecular: 354.500 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 13
• Exact Mass: 354.241 Da
• Monoisotopic Mass: 354.241 Da
• Topological Polar Surface Area: 94.800 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 432.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Referencias

1. Zhang Xiaoning, Liang Min, Song Dandan, Huang Rongzu, Chen Chen, Liu Xiaojun, Chen Houyang, Wang Qingxin, Sun Xiaoli, Song Jian, Zhang Jiali, Kang Hang, Zeng Xuhui.  (2024)  Both protein and non-protein components in extracellular vesicles of human seminal plasma improve human sperm function via CatSper-mediated calcium signaling.  HUMAN REPRODUCTION,      [PMID:38335261] [10.1093/humrep/deae018]

2. Ning Yu, Shule Zhang, Rui Fang, Yingxin Zhang, Xi Xu, Lijuan Cao, Jianfa Zhang.  (2025)  Selective thrombolysis through fibrin network destabilization: An unrecognized heparin analog mechanism.  PHARMACOLOGICAL RESEARCH,      [PMID:40976458] [10.1016/j.phrs.2025.107961]

3. Xiaoying Wang, Xiaoxing Fang, Xuewei Li, Hejiang Cheng, Hua Jiang, Ji Zheng.  (2025)  A colorimetric assay developed for the evaluation of tumor cell-platelet interaction and drug intervention.  TALANTA,      [PMID:40946479] [10.1016/j.talanta.2025.128836]

4. Lili Wang, Yunqian Li, Ran Guo, Shanshan Li, Anqi Chang, Zhixiang Zhu, Pengfei Tu.  (2019)  Optimized bioluminescence analysis of adenosine triphosphate (ATP) released by platelets and its application in the high throughput screening of platelet inhibitors.  PLoS One,  14  (10): (e0223096).  [PMID:31600247] [10.1371/journal.pone.0223096]

5. Yue Li, Yayue Zhang, Xuran Ding, Taotao Zou, Hu Li, Ke Xu, Cheng Su, Yuting Wang, Ziming Zhao, Yuan He.  (2025)  Tailored platelet biomimetic delivery platform for targeted therapy of inflammatory bowel disease.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.166357]

6. Hao Li, Xiaowei Xie, Yu Zhang, Xiaopeng Han, Ting Shi, Jiayin Li, Wanyu Chen, Qin Wei, Hong Pan, Shuxian Xu, Qiuyu Chen, Lifang Yin, Chao Qin.  (2025)  MOF-Engineered Platelet-Mimicking Nanocarrier-Encapsulated Cascade Enzymes for ROS Scavenging and Anti-Inflammation in Cerebral Ischemia–Reperfusion Injury.  Pharmaceutics,  17  (11): (1478).  [PMID:41304816] [10.3390/pharmaceutics17111478]

7. Tianjiao Hao, Bin Gao, Yuanyuan Zhou, Chang Liu, Chuanjiang Ran, Binghua Chang, Wei You, Qiyue Wang, Jun Ye, Yan Shen.  (2026)  A spatiotemporal selective bioinspired hybrid system engineered for preventing post-thrombolysis recurrence by inhibiting the ferroptosis pathway and reprogramming macrophages.  Acta Pharmaceutica Sinica B,      [PMID:] [10.1016/j.apsb.2026.01.014]