PTIO - ≥98%(T) , CAS No.18390-00-6

CAS: 18390-00-6 Cat. No.: P160514 Peso molecular: 233.29 Número EC: 634-050-5 PubChem CID: 2733513

GRADE & PURITY ≥98%(T)

Synonyms

PTIO | MFCD00059929 | 1H-Imidazol-1-yloxy, 4,5-dihydro-4,4,5,5-tetramethyl-2-phenyl-, 3-oxide | PTIO (2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) | A5440 | 4,5-Dihydro-4,4,5,5-tetramethyl-2-phenyl-1H-imidazol-1-yloxy-1-oxide | 2-phenyl-4,4,5,5

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Specifications

Sinónimos

PTIO | MFCD00059929 | 1H-Imidazol-1-yloxy, 4, 5-dihydro-4, 4, 5, 5-tetramethyl-2-phenyl-, 3-oxide | PTIO (2-Phenyl-4, 4, 5, 5-tetramethylimidazoline-3-oxide-1-oxyl) | A5440 | 4, 5-Dihydro-4, 4, 5, 5-tetramethyl-2-phenyl-1H-imidazol-1-yloxy-1-oxide | 2-phenyl-4, 4, 5, 5

Especificaciones y pureza

≥98%(T)

Mecanismos bioquímicos y fisiológicos

2-phenyl-4, 4, 5, 5, -tetramethylimidazoline-1-oxyl 3-oxide (PTIOs) derivatives react with nitric oxide (NO) to yield the corresponding imino nitroxides (PTIs) and nitrogen dioxide (NO2).A stable radical scavenger for nitric oxide; affects NO without affec

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%(T)

Nombres e identificadores

• Pubchem Sid: 504761011
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504761011
• Sonrisas canónicas: CC1(C([N+](=C(N1[O])C2=CC=CC=C2)[O-])(C)C)C
• InChIKey: DYUUGILMVYJEHY-UHFFFAOYSA-N
• INCHI: 1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3
• Isómeros SMILES: CC1(C([N+](=C(N1[O])C2=CC=CC=C2)[O-])(C)C)C
• PubChem CID: 2733513
• Peso molecular: 233.29
• Reaxy-Rn: 13743042

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzene and substituted derivatives
• Alternative Parents: Imidazolines Nitrones Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Monocyclic benzene moiety - 2-imidazoline - Nitrone - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

PC-12 (7051 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in methanol.
• Sensibilidad: heat sensitive；light sensitive
• Peso molecular: 233.290 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 233.129 Da
• Monoisotopic Mass: 233.129 Da
• Topological Polar Surface Area: 33.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 316.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Mengge Feng, Xuelian Zeng, Quan Lin, Yunxiao Wang, Hongjiang Wei, Shanyi Yang, Guangwei Wang, Xingyu Chen, Mengqin Guo, Xin Yang, Jun Hu, Yangge Du, Yanbing Zhao, Yufeng Zhang, Xiangliang Yang.  (2023)  Characterization of Chitosan-Gallic Acid Graft Copolymer for Periodontal Dressing Hydrogel Application.  Advanced Healthcare Materials,      [PMID:38041691] [10.1002/adhm.202302877]

2. Yiping Wu, Lulu Du, Xiaoning Xu, Yuhan Hu, Jia Liu, Jingwei Zhang, Lei Lei, Wenfang He, Zihao Sheng, Yuanao Ni, Jia Qu, Xingyi Li, Jun Jiang.  (2023)  Nano Self-Assemblies of Caffeic Acid–Fibronectin Mimic a Peptide Conjugate for the Treatment of Corneal Epithelial Injury.  MOLECULAR PHARMACEUTICS,      [PMID:37871179] [10.1021/acs.molpharmaceut.3c00861]

3. Lin Zhao, Jing Zhang, Jun Ma.  (2023)  PTIO as a redox mediator to enhance organic contaminants oxidation by permanganate.  WATER RESEARCH,      [PMID:37633207] [10.1016/j.watres.2023.120500]

4. Zhi-Tong Zhang, Yue Jiang, Yali Qi, Huanhuan Guan, Lei Bai, Pan Chen, Wufeng Gao, Guo-Dong Zhuang, Tulin Lu, Guojun Yan.  (2023)  Comparative study on Angelica sinensis after different processing with yellow rice wine in color, aromas, chemical components, and antioxidant activities.  Food Chemistry-X,      [PMID:37780300] [10.1016/j.fochx.2023.100822]

5. Si-Yu Gui, Xin-Chen Wang, Zhi-Hao Huang, Mei-Mei Li, Jia-Hao Wang, Si-Yin Gui, Gan-Hua Zhang, Yao Lu, Li-Ming Tao, Hai-Sheng Qian, Zheng-Xuan Jiang.  (2023)  Nanoscale Coordination Polymer Fe-DMY Downregulating Poldip2-Nox4-H2O2 Pathway and Alleviates Diabetic Retinopathy.  Journal of Pharmaceutical Analysis,      [PMID:38174114] [10.1016/j.jpha.2023.05.002]

6. Huitong Luo, Zetao Wang, Zhichao He, Zemin Ling, Hao Wang, Jiayi Zhu, Jingjun Nie, Dafu Chen, Qi Feng, Xiaodong Cao.  (2023)  Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation.  Biomaterials Science,  11  (10): (3629-3644).  [PMID:37010367] [10.1039/D3BM00359K]

7. Qiongdan Hu, Ruyu Ma, Xinxing Tang, Rui Long, Qi Wang, Chaomei Fu, Rui Li, Hang Xiao.  (2022)  Self-assembled nanoparticles of curcuminoids and soluble dietary fibers: Characterization and mechanism.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2022.114375]

8. Zuyu He, Yunhao Liu, Hui Wang, Puwang Li, Yu Chen, Chao Wang, Chuang Zhou, Shuhui Song, Shaohua Chen, Guocong Huang, Ziming Yang.  (2022)  Dual-grafted dextran based nanomicelles: Higher antioxidant, anti-inflammatory and cellular uptake efficiency for quercetin.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:36306905] [10.1016/j.ijbiomac.2022.10.222]

9. Jun Cheng, Qun Liu, Yucang Zhang, Zhifen Wang, Mengmeng Gao, Siyuan Li.  (2021)  Preparation and properties of antibacterial and antioxidant mango peel extract/polyvinyl alcohol composite films.  JOURNAL OF FOOD PROCESSING AND PRESERVATION,  46  (1): (e16206).  [PMID:] [10.1111/jfpp.16206]

10. Jun Cheng, Xiaotong Lin, Xialing Wu, Qun Liu, Shoumei Wan, Yucang Zhang.  (2021)  Preparation of a multifunctional silver nanoparticles polylactic acid food packaging film using mango peel extract.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:34343590] [10.1016/j.ijbiomac.2021.07.161]

11. Danwei Yue, Weirong Cai, Bole Ding, Han Zhu, Jingjing Li, Yin Zhu.  (2021)  Separation and preparation of the main flavonoids in Flos Dolichoris Lablab and their antioxidant activity.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:] [10.3136/fstr.27.429]

12. Juanjuan Yao, Huiying Zhang, Longfu Chen, Wei Liu, Naiyun Gao, Shiyi Liu, Xiangyu Chen, Fanghui Rao.  (2020)  The Roles of Sono-induced Nitrosation and Nitration in the Sono-degradation of Diphenylamine in Water: Mechanisms, Kinetics and Impact Factors.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:33254758] [10.1016/j.jhazmat.2020.123720]

13. Jumin Yang, Wenguang Liu, Wei Wang.  (2024)  A supramolecular hydrogel leveraging hierarchical multi-strength hydrogen-bonds hinged strategy achieving a striking adhesive-mechanical balance.  Bioactive Materials,      [PMID:39318637] [10.1016/j.bioactmat.2024.09.014]

14. Fanyi Guo, Jianfeng Li, Ziyu Chen, Tianxiao Wang, Ruyu Wang, Tianyao Wang, Yifeng Bian, Yifei Du, Hua Yuan, Yongchu Pan, Jianliang Jin, Huijun Jiang, Feng Han, Jiandong Jiang, Fan Wu, Yuli Wang.  (2024)  An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing.  ACS Applied Materials & Interfaces,      [PMID:38727024] [10.1021/acsami.4c03278]

15. Liping Yu, Wang Cheng, Meifen Tian, Zhigang Wu, Xiaoli Wei, Xing Cheng, Mingwei Yang, Xuan Ma.  (2024)  Antioxidant Activity and Volatile Oil Analysis of Ethanol Extract of Phoebe zhennan S. Lee et F. N. Wei Leaves.  Forests,  15  (2): (236).  [PMID:] [10.3390/f15020236]

16. Bin Cheng, Jie Zhou, Xu Wang, Zihan He, Zhengyi Xu, Jian Wang, Junyu Chen, Zhou Zhu, Weifeng Zhao, Qianbing Wan, Xibo Pei.  (2024)  Dual-responsive metal polyphenol network nanosheets for diabetic wound healing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.153071]

17. Ziwen Wang, Dongdong Wang, Jiaxuan Fang, Zixin Song, Jiman Geng, Jianfei Zhao, Yifan Fang, Changtao Wang, Meng Li.  (2024)  Green and efficient extraction of flavonoids from Perilla frutescens (L.) Britt. leaves based on natural deep eutectic solvents: Process optimization, component identification, and biological activity.  FOOD CHEMISTRY,      [PMID:38733681] [10.1016/j.foodchem.2024.139508]

18. Xiang Li, Wenli Han, Gao He, Jiahao Yang, Jing Li, Hongxia Ma, Shige Wang.  (2024)  Hydrogel-Transformable Antioxidant Poly-γ-Glutamic Acid/Polyethyleneimine Hemostatic Powder for Efficient Wound Hemostasis.  Gels,  10  (1): (68).  [PMID:38247790] [10.3390/gels10010068]

19. Gang Feng, Yifan Wu, Xinzi He, Tingting Ye, Shang Chi, Xiaoxiao Ji, Jiawei Kang, Kaicheng Xu, JinFeng Zhou, Zhihui Xiang, Wei Wang, Yaping Li, Yiying Qi.  (2025)  Lubricated hydrogel with STING-inhibiting EXOs protect the osteoarthritis by suppressing the senescent microenvironment.  Nano Today,      [PMID:] [10.1016/j.nantod.2025.102688]

20. Zhiqing Liu, Tianlong Wang, Lei Zhang, Yiping Luo, Jinhui Zhao, Yixing Chen, Yao Wang, Wentao Cao, Xinyu Zhao, Bingqiang Lu, Feng Chen, Zifei Zhou, Longpo Zheng.  (2024)  Metal–Phenolic Networks-Reinforced Extracellular Matrix Scaffold for Bone Regeneration via Combining Radical-Scavenging and Photo-Responsive Regulation of Microenvironment.  Advanced Healthcare Materials,      [PMID:38319101] [10.1002/adhm.202304158]

21. Zhibin Ren, Xiaoying Liu, Guanghao Lv, Xiaiting Wang, Jingli Wang, Wei Wu, Xingyi Li, Jiaqing Wang.  (2025)  Mitochondrial Localization of Antioxidant Nanodrug Suppresses Ocular Inflammation by Alleviating Oxidative Stress on Cells.  CHEMISTRY-A EUROPEAN JOURNAL,      [PMID:39833114] [10.1002/chem.202402441]

22. Shun Xiao, Xiaozhi Sun, Chong Wang, Jianlie Wu, Kun Zhang, Mingjin Guo, Bing Liu.  (2024)  Nanomicrosphere sustained-release urokinase systems with antioxidant properties for deep vein thrombosis therapy.  RSC Advances,  14  (10): (7195-7205).  [PMID:38419677] [10.1039/D3RA07221E]

23. Liya Fan, Xiaoxuan Xi, Xiaoyan Zhao, Xiao Zhu.  (2024)  Preparation of composite hydrogel with mechanical stability and temperature response for tea polyphenol release.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2024.135831]

24. Enhui Xu, Hainan Yu, Wei Wu, Bolin Ji, Xueling Feng, Hong Xu, Yi Zhong, Bijia Wang, Zhiping Mao.  (2024)  Preparation of high antioxidant nanolignin and its application in cosmetics.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38797295] [10.1016/j.ijbiomac.2024.132635]

25. Wenjing Ma, Mingjun Tang, Siying Li, Yongqun Ma, Min Ling, Wenqian Sheng.  (2024)  The effect of hydrogen bonding strength in natural deep eutectic solvents on the extraction efficiency of polyphenols.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.112379]

26. Mingjun Tang, Min Ling, Wenjing Ma, Wenqian Sheng, Wenjun Yan.  (2025)  The Elucidation of the Critical Role of HLB value in Microemulsions Formulation.  ChemNanoMat,      [PMID:] [10.1002/cnma.202400554]

27. Yi Wang, Xuemei Liao, Qinglong Guo, Heng Zhang, Lei Ye, Liangchen Yu, Xiaoming Kong, Yicheng Jiang, Peng Zhao, Kaiyong Cai, Hongwei Cheng.  (2025)  Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation.  Bioactive Materials,      [PMID:40678266] [10.1016/j.bioactmat.2025.06.033]

28. Xinting Feng, Zhiwen Luo, Wei Zhang, Renwen Wan, Yisheng Chen, Fangqi Li, Yanwei He, Zhiheng Lin, James Hoipo Hui, João Conde, Shiyi Chen, Zhijie Zhao, Xianwen Wang.  (2025)  Zn-DHM Nanozymes Enhance Muscle Regeneration Through ROS Scavenging and Macrophage Polarization in Volumetric Muscle Loss Revealed by Single-Cell Profiling.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202506476]

29. Xiaoli Qin, Yan Lu, Yawen Luo, Yafang Cui, Kai Zhao, Yang He, Muhammad Aziz ur Rahman, Shengnan Min, Wenfang Wang, Fuyu Yang, Binghai Cao, Huawei Su.  (2025)  Alfalfa Flavonoids Mitigate Salmonella-Induced Colitis via the Keap1-Nrf2 and TLR4/NF-κB/COX-2 Pathways.  Food Frontiers,      [PMID:] [10.1002/fft2.70036]

30. Xiaoyi Zheng, Yijie Xie, Linlin Zhao, Xiaojuan Huang, Shige Wang, Yongkang Lai, Peng Fan, Yanbo Zeng, Jiulong Zhao, Zhaoshen Li.  (2025)  Chitosan-sodium tripolyphosphate-zinc nanogel for synergistic hydrogen and ion release to eradicate Helicobacter pylori and promote gastric mucosal healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41274475] [10.1016/j.ijbiomac.2025.149171]

31. Shuo Tan, Hua Zeng, Wenshuya Li, Haibo Liu, Xuefeng Gu, Xiong Luo, Xinyu Zhao.  (2025)  Copper Nanocluster-Decorated Magnesium Silicate-Based Microneedle Enhances Antimicrobial Effects and Tissue Remodeling for Diabetic Wounds.  Small Science,      [PMID:41537187] [10.1002/smsc.202500442]

32. Zheng Cheng, Jikang Cao, Haobo Lin, Yuchen Wang, Ran Qin, Yuhao Ruan, Xinyu Hu, Jingxuan Cang, Chang Sun, Dong Qiu, Yifeng Bian, Yifei Du, Yongchu Pan.  (2025)  Cu–Fe3O4 Nanozyme Reverses Age-Impaired Alveolar Healing via Reactive Oxygen–Nitrogen Species Scavenging and Mitophagy Reactivation.  LANGMUIR,      [PMID:41347738] [10.1021/acs.langmuir.5c04365]

33. Zhang Liu, Zile Shen, Hengli Lu, Bingqiang Lu, Peng Zhang, Wenhao Chen, Guowei Huang, Xinyu Qu, Zhen Yu, Feng Chen, Wangfu Zang.  (2025)  Muscle-Targeted Nanocomposite Therapy Alleviates Age-Related Sarcopenia via Antioxidant and Metabolic Reprogramming.  ACS Nano,      [PMID:41468174] [10.1021/acsnano.5c18226]

34. Yongkang Lai, Yongliang Ouyang, Xiaojing Yin, Tao Yu, Jianhua Wan, Xueyang Li, Yi Hu, Xu Shu, Huan Wang.  (2026)  Engineered Targeted Ce-Based MOF Nanozymes for ROS Scavenging and Inflammatory Reprogramming in Chronic Pancreatitis.  Materials Today Bio,      [PMID:41660130] [10.1016/j.mtbio.2026.102811]

35. Dong Liu, Songkai Zhu, Jiayang Li, Yuexing Zhang, Yu Xia, Yong Liang, Bolei Chen.  (2026)  Generation of Nitrite from Residual Urea on Leafy Vegetables Caused by Water Vapor Condensation.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41746764] [10.1021/acs.est.5c16384]

36. Jia Chen, Minghui He, Junxiao Li, Yunqi Shen, Xinkun Shen, Min Lai.  (2026)  Mn-TA nanoparticle-reinforced hydrogel coating on TiO2 nanotube implants for enhanced osseointegration via antioxidant, anti-inflammatory, and osteogenic activities.  Biomaterials Advances,      [PMID:] [10.1016/j.bioadv.2026.214824]

37. Zizhao Wang, Yang Yang, Hongxin Sun, Peng Fan, Xiaoqing Jia, Liang Zhang, Ting Wang, Jiulong Zhao, Qian Chen, Shige Wang.  (2026)  A Perioperative Hydrogel Platform for Integrated Endoscopic Submucosal Dissection Management.  ACS Applied Materials & Interfaces,      [PMID:] [10.1021/acsami.6c01648]