QX77 - 10mM in DMSO , CAS No.1798331-92-6

CAS: 1798331-92-6 Cat. No.: Q422191 Fórmula: C₁₆H₁₃ClN₂O₂ Peso molecular: 300.74 PubChem CID: 118129505

CALIDAD & PUREZA 10mM in DMSO

Synonyms

N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide；N-(4-(7-Chloro-2H-benzo[b][1,4]oxazin-3-yl)phenyl)acetamide；QX 77；QX-77

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

QX77 is a novel activator ofchaperone-mediated autophagy (CMA). QX77 induces the up-regulation of Rab11 expression and up-regulates LAMP2A expression.

Product description：

QX77 is a chaperone-mediated autophagy (CMA) activator.

Especificaciones

Sinónimos

N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide；N-(4-(7-Chloro-2H-benzo[b][1,4]oxazin-3-yl)phenyl)acetamide；QX 77；QX-77

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 that activates CMA by antagonizing retinoic acid receptor-α (RARα) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAM

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

Pubchem Sid

528766829

Sonrisas canónicas

CC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2

IUPAC Name

N-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide

InChIKey

PYCTUCLCTVWILY-UHFFFAOYSA-N

INCHI

1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-8H,9H2,1H3,(H,18,20)

Isómeros SMILES

CC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2

PubChem CID

118129505

Peso molecular

300.74

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzoxazines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoxazines
• Alternative Parents: Acetanilides N-acetylarylamines Alkyl aryl ethers Aryl chlorides Acetamides Secondary carboxylic acid amides Ketimines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoxazine - Acetanilide - N-acetylarylamine - Anilide - N-arylamide - Alkyl aryl ether - Benzenoid - Monocyclic benzene moiety - Aryl halide - Aryl chloride - Acetamide - Secondary carboxylic acid amide - Ketimine - Carboxamide group - Oxacycle - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Ether - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Imine - Carbonyl group - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzoxazines. These are organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Peso molecular: 300.740 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 300.067 Da
• Monoisotopic Mass: 300.067 Da
• Topological Polar Surface Area: 50.700 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 419.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1