(R)-DNMDP - 10mM in DMSO , CAS No.1630760-60-9

CAS: 1630760-60-9 Cat. No.: D654638 Peso molecular: 304.34 PubChem CID: 7122097

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC 50 compared to the (S)-enantiomer in HeLa cell line.

In Vitro

(R)-DNMDP (0.1 pM-1 mM; for 48 hours) has a 500-fold lower EC 50 compared to the (S)-enantiomer in HeLa cell line. (S)-DNMDP has non-cytotoxic. Binding of PDE3A to the linker analogue is blocked by both trequinsin and (R)-DNMDP, but not by the (S)-DNMDP. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC 50 compared to the (S)-enantiomer in HeLa cell line.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CCN(CC)C1=C(C=C(C=C1)C2=NNC(=O)C[C@H]2C)[N+](=O)[O-]
• PubChem CID: 7122097
• Peso molecular: 304.34