(Rac)-ZLc-002 - ≥98% , CAS No.R658735

CAS: R658735 Cat. No.: R658735 Peso molecular: 231.25

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

(Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP) , suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel ( HY-B0015 ) to reduce tumor cell viabilit

Appearance:Solid

IC50& Target:nNOS/NOS1AP interaction

In Vitro:(Rac)-ZLc-002 (10 μM) reduces co-immunoprecipitation of NOS1AP with nNOS immunoprecipitated from primary cultured cortical neurons. (Rac)-ZLc-002 fails to disrupt nNOS–NOS1AP protein–protein interactions in the AlphaScreen in vitro binding assay. It shows

In Vivo:(Rac)-ZLc-002 (10mg/kg; i.p.; once or daily for 8 days) attenuates mechanical and cold allodynia evoked by Paclitaxel (HY-B0015), suppresses Paclitaxel-induced neuropathic pain in a mouse model. (Rac)-ZLc-002 (4 and 10mg/kg; i.p.; once) reduces for

Biological Activity:(Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP) , suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel ( HY-B0015 ) to reduce tumor cell viabilit

Specifications

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 231.25