Radezolid - Moligand™, ≥96% , Bacterial 70S ribosome inhibitor, CAS No.869884-78-6, Bacterial 70S ribosome inhibitor

CAS: 869884-78-6 Cat. No.: R126228 Peso molecular: 438.45 PubChem CID: 11224409

GRADE & PURITY Moligand™, ≥96%

Synonyms

RX-013 | rx103 | RX-103 | UNII-53PC6LO35W | MMV688327 | Radezolid | RX1741 | RX-1741 | RX-01_667 | N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against Staphylococcus, Chlamydia, and Legionella species, and remains active against Linezolid-resistant strains.

Specifications

Sinónimos

RX-013 | rx103 | RX-103 | UNII-53PC6LO35W | MMV688327 | Radezolid | RX1741 | RX-1741 | RX-01_667 | N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1, 2, 3-triazol-5-ylmethyl)amino]methyl][1, 1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Especificaciones y pureza

Moligand™, ≥96%

Mecanismos bioquímicos y fisiológicos

Radezolid (INN, codenamed RX-1741) is a novel oxazolidinone antibiotic being developed by Rib-X Pharmaceuticals, Inc. for the treatment of serious multi-drug–resistant infections. Radezolid has completed two phase-II clinical trials

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Bacterial 70S ribosome inhibitor

Pureza

≥96%

Propiedades del producto

• ALogP: 1.1

Nombres e identificadores

• Sonrisas canónicas: CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
• IUPAC Name: N-[[(5S)-3-[3-fluoro-4-[4-[(2H-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• InChIKey: BTTNOGHPGJANSW-IBGZPJMESA-N
• INCHI: 1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1
• Isómeros SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
• PubChem CID: 11224409
• Peso molecular: 438.45

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Phenylmethylamines Benzylamines Aralkylamines Fluorobenzenes Aryl fluorides Oxazolidinones Triazoles Carbamate esters Heteroaromatic compounds Dialkylamines Carboximidic acids Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organofluorides Carbonyl compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Biphenyl - Benzylamine - Phenylmethylamine - Fluorobenzene - Aralkylamine - Halobenzene - Aryl fluoride - Aryl halide - Oxazolidinone - Azole - Heteroaromatic compound - Oxazolidine - Carbamic acid ester - 1,2,3-triazole - Oxacycle - Carboximidic acid - Carboximidic acid derivative - Secondary aliphatic amine - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Secondary amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Amine - Carbonyl group - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

THP-1 (11052 Activities)

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HUVEC (11049 Activities)

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Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

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Streptococcus (3973 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Chlamydia pneumoniae (241 Activities)

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Legionella pneumophila (143 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Staphylococcus hominis (482 Activities)

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Moraxella catarrhalis (3334 Activities)

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Haemophilus influenzae (8812 Activities)

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Chlamydia trachomatis (699 Activities)

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Staphylococcus (1598 Activities)

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Streptococcus pyogenes (16140 Activities)

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Enterococcus faecium (13803 Activities)

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Listeria monocytogenes (2626 Activities)

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Mycoplasmoides pneumoniae (351 Activities)

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Enterococcus faecalis (29875 Activities)

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Staphylococcus capitis (242 Activities)

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J774 (3120 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Metamycoplasma hominis (88 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO
• Peso molecular: 438.500 g/mol
• XLogP3: 1.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 438.182 Da
• Monoisotopic Mass: 438.182 Da
• Topological Polar Surface Area: 112.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 647.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1