GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Bioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.His Tag?His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein.PBS Only?PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers.≥95%(SDS-PAGE)
Expression System
HEK293
Accession #
P30530
Protein Tag
C-His
Expression system
HEK293
Endotoxin Concentration
<1.0 EU/μg
Bioactivity
1. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC50 of 11.51 ng/mL. 2. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Enapotamab (anti-AXL) (Ab177845) with the EC50 of 2.766 ng/mL.
Animal Free,Carrier Free,Bioactive,ActiBioPure™,His Tag,PBS Only,≥95%(SDS-PAGE) ActiBioPure™,Animal Free,Bioactive,Carrier Free,His Tag,PBS Only for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. TAM family receptors (Dtk/Tyro3, Axl, and Mer) are involved in regulation of the inflammatory response, cell survival and migration, and tumorigenesis. Mature human Axl consists of a 426 aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain that includes the tyrosine kinase domain. Within the ECD, human Axl shares approximately 82% aa sequence identity with mouse and rat Axl. A short alternately spliced form of human Axl has a 9 aa deletion in the extracellular juxtamembrane region. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Activation of Axl induces a broad range of activities including platelet aggregation and thrombus formation, macrophage and dendritic cell phagocytosis of apoptotic cells, NK cell development from hematopoietic progenitor cells, and in vivo angiogenesis. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It contributes to vascular remodeling and inflammatory cell infiltration in response to hypertension and restricted blood flow. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. A 70-80 kDa soluble portion of the Axl ECD can be shed by proteolytic cleavage, and this fragment retains the ability to bind Gas6.
Specifications
Product Name
Recombinant Human Axl Protein
Sinónimos
AI323647 | Adhesion related kinase | Ark | Axl | AXL oncogene | AXL receptor tyrosine kinase | AXL transforming gene | AXL transforming sequence/gene | EC 2.7.10.1 | JTK11 | Oncogene AXL | Tyro7 | Tyrosine protein kinase receptor UFO | Tyrosine-protein ki
Grado
ActiBioPure™, Animal Free, Bioactive, Carrier Free, His Tag, PBS Only
1. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC50 of 11.51 ng/mL. 2. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Enapotamab (anti-AXL) (Ab177845) with the EC50 of 2.766 ng/mL.
53.9-77.0 kDa, under reducing conditions; 49.3-70.8 kDa, under non-reducing conditions
Tipo de molécula
Protein
Almacenamiento y envío
Reconstitución
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Condiciones de almacenamiento de almacenamiento
Store at -20°C,Avoid repeated freezing and thawing
Enviado en
Ice chest + Ice pads
Estabilidad y almacenamiento
Store at -20°C for 1 year. Avoid freeze / thaw cycle.
Imágenes
Recombinant Human Axl Protein (rp183600) - ELISA Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC50 of 11.51 ng/mL.
Recombinant Human Axl Protein (rp183600) - ELISA Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Enapotamab (anti-AXL) (Ab177845) with the EC50 of 2.766 ng/mL.
Recombinant Human Axl Protein (rp183600) - SDS-PAGE 3 μg/lane of Recombinant Human Axl Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 53.9-77.0 kDa under reducing conditions and 49.3-70.8 kDa under non-reducing conditions.
Recombinant Human Axl Protein (rp183600) - ELISA Immobilized Recombinant Human AXL protein (rp183600) at 1.0 μg/mL can bind Mipasetamab (anti-AXL) (Ab183002) with the EC
₅₀
of 24.0 ng/mL.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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