GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Bioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.His Tag?His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein.PBS Only?PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers.≥95%(SDS-PAGE)
Expression System
HEK293
Accession #
P00533
Protein Tag
C-His
Expression system
HEK293
Endotoxin Concentration
<1.0 EU/μg
Bioactivity
Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 25.83 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 28.96 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC50 of 45.18 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Serclutamab (anti-EGFR) (Ab182867) with the EC50 of 35.7 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 23.66 ng/mL.
Animal Free,Carrier Free,Bioactive,ActiBioPure™,His Tag,PBS Only,≥95%(SDS-PAGE) ActiBioPure™,Animal Free,Bioactive,Carrier Free,His Tag,PBS Only for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Protein Function： As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Specifications
Product Name
Recombinant Human EGFR Protein
Sinónimos
cell growth inhibiting protein 40 | avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | cell proliferation-inducing protein 61 | EC 2.7.10 | EC 2.7.10.1 | EGF R | EGFR | epidermal growth factor receptor (avian erythroblastic leukemia viral (v
Grado
ActiBioPure™, Animal Free, Bioactive, Carrier Free, His Tag, PBS Only
Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 25.83 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 28.96 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC50 of 45.18 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Serclutamab (anti-EGFR) (Ab182867) with the EC50 of 35.7 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 23.66 ng/mL.
99.6 kDa, under reducing conditions; 99.6 kDa, under non-reducing conditions
Tipo de molécula
Protein
Almacenamiento y envío
Reconstitución
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Condiciones de almacenamiento de almacenamiento
Store at -20°C,Avoid repeated freezing and thawing
Enviado en
Ice chest + Ice pads
Estabilidad y almacenamiento
Store at -20°C for 1 year. Avoid freeze / thaw cycle.
Imágenes
Recombinant Human EGFR Protein (rp176273) - ELISA Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC₅₀ of 25.83 ng/mL.
Recombinant Human EGFR Protein (rp176273) - ELISA Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 28.96 ng/mL.
Recombinant Human EGFR Protein (rp176273) - ELISA Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC₅₀ of 45.18 ng/mL.
Recombinant Human EGFR Protein (rp176273) - ELISA Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Serclutamab (anti-EGFR) (Ab182867) with the EC₅₀ of 35.7 ng/mL.
Recombinant Human EGFR Protein (rp176273) - ELISA Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC₅₀ of 17.44 ng/mL.
Recombinant Human EGFR Protein (rp176273) - ELISA Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC₅₀ of 23.66 ng/mL.
Recombinant Human EGFR Protein (rp176273) - SDS-PAGE 2 μg/lane of Recombinant Human EGFR Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 99.6 kDa.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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