GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Bioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.His Tag?His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein.PBS Only?PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers.≥90%(SDS-PAGE)
Expression System
HEK293
Accession #
P21860
Protein Tag
C-His
Expression system
HEK293
Endotoxin Concentration
<1.0 EU/μg
Bioactivity
Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.
ActiBioPure™, bioactivo, sin animales, sin portador, ≥90%(SDS-PAGE) ActiBioPure™,Animal Free,Bioactive,Carrier Free,His Tag,PBS Only for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Conservar a -20°C,Evitar la congelación y descongelación repetidas Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Función de la proteína:： ErbB3, también conocido como Her3(receptor del factor de crecimiento epidérmico humano3), es un miembro de la familia del receptor del factor de crecimiento epidérmico (EGFR) de los receptores tirosina quinasas. Esta glicoproteína unida a la membrana tiene un dominio de unión a neuregulina, pero no tiene un dominio de quinasa activa, por lo que no puede mediar en la transducción de señales intracelulares a través de la fosforilación de proteínas. Sin embargo, su heterodímero con ErbB2 u otros miembros del EGFR responsables de la fosforilación de tirosina forma un complejo receptor con alta afinidad, e inicia la vía relacionada que conduce a la proliferación o diferenciación celular. Se ha demostrado que ErbB3 está implicado en numerosos tipos de cáncer, como los de próstata, vejiga y mama. Esta proteína tiene diferentes isoformas derivadas de variantes alternativas de splicing, y entre ellas, la isoforma secretada que carece de la región intermembrana modula la actividad de la forma unida a la membrana.
ActiBioPure™, Animal Free, Bioactive, Carrier Free, His Tag, PBS Only
Especificaciones y pureza
ActiBioPure™, bioactivo, sin animales, sin portador, ≥90%(SDS-PAGE)
Bioactividad
Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.
81.5-101.9 kDa, under reducing conditions; 74.3-99.3 kDa, under non-reducing conditions
Tipo de molécula
Protein
Almacenamiento y envío
Reconstitución
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Condiciones de almacenamiento de almacenamiento
Conservar a -20°C,Evitar la congelación y descongelación repetidas
Enviado en
Hielera + almohadillas de hielo
Estabilidad y almacenamiento
Conservar a -20°C durante 1 año. Evitar el ciclo de congelación/descongelación.
Imágenes
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.
Recombinant Human ErbB3/HER3 Protein (rp170123) - SDS-PAGE 3 μg/lane of Recombinant Human ErbB3/HER3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 81.5-101.9 kDa under reducing conditions and 74.3-99.3 kDa under non-reducing conditions.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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