Carrier Free,His-Tag,≥90%(SDS-PAGE),See COA Carrier Free,His Tag for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
IMPDH2 (inosine monophosphate dehydrogenase) is one of two cytosolic and nuclear enzyme isoforms that play a central role in guanine nucleotide metabolism. The isoforms are 84% identical but distinctly regulated. While IMPDH1 is generally constitutively expressed, IMPDH2 is inducible during proliferation and transformation. Both isoforms form a homotetramer of approximately 55 kDa monomers containing a catalytic barrel domain and a subdomain with two cystathione beta-synthase domains which mediate RNA and DNA binding. Both enzymes catalyze the NAD-dependent conversion of inosine monophosphate (IMP) to hypoxanthine monophosphate (XMP) which is a precursor for the synthesis of GMP, guanosine, and guanine. These compounds are critical for DNA synthesis and cell proliferation which explains the importance of IMPDH in cancer and viral infection. Although IMPDH1 and IMPDH2 are known to be inhibited by the immunosuppressant drug mycophenolic acid (MPA), much research has targeted discovery of additional and selective inhibitors for IMPDH isoforms given they are targets for several major therapeutic areas. Human IMPDH2 shares 99% amino acid sequence identity with mouse IMPDH2.
Post-translational: Ubiquitinated leading to its degradation by the proteasome.The N-terminus is blocked.Acetylated by CLOCK in a circadian manner (PubMed:28985504).
Recombinant Human IMP Dehydrogenase 2/IMPDH2 Protein (rp231843) - SDS-PAGE
3 μg/lane of Recombinant Human IMP Dehydrogenase 2/IMPDH2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 53.2 kDa under reducing conditions and 52.2 kDa under non-reducing conditions.
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 ZJ25F0927550 | Certificate of Analysis | Jul 12, 2026 | rp231843 |
| ZJ25F0927551 | Certificate of Analysis | Jul 12, 2026 | rp231843 |
| ZJ25F0927552 | Certificate of Analysis | Jul 12, 2026 | rp231843 |
| ZJ25F0927553 | Certificate of Analysis | Jul 12, 2026 | rp231843 |
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