Remdesivir (GS-5734) - Moligand™, 10mM in DMSO , Replicase polyprotein 1ab inhibitor, CAS No.1809249-37-3, Replicase polyprotein 1ab inhibitor

CAS: 1809249-37-3 Cat. No.: R408405 Peso molecular: 602.58 Número EC: 852-825-8 PubChem CID: 121304016

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrumantiviralagent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
In vitro

GS-5734 exhibits antiviral activity against multiple variants of EBOV in cell-based assays(EC50=0.06-0.14 μM) and broad-spectrum antiviral activity in vitro against other pathogenic RNA viruses. GS-5734 acts as a broad-spectrum therapeutic to protect against CoVs with EC50 of 0.03 μM for murine hepatitis virus in delayed brain tumor cells and 0.074 μM for SARS-CoV and MERS-CoV in HAE cells.

In vivo

Regardless of the time of initiation, GS-5734 treatment confers improved survival when administered by 3 mg/kg GS-5734. All animals in which 10 mg/kg GS-5734 treatments is initiated 3 days after virus exposure survive to the end of the in-life phase. However, the antiviral effects are consistently greater in animals administered repeated 10 mg/kg GS-5734 doses. The 10 mg/kg D3 (administered beginning 3 days after virus exposure) GS-5734 regimen is associated with amelioration of EVD-related clinical disease signs and markers of coagulopathy and end organ pathophysiology.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2, 1-f][1, 2, 4]triazin-7-yl)-2, 5-anhydro-D-altrononitrile

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Replicase polyprotein 1ab inhibitor

Propiedades del producto

• ALogP: 1.9

Nombres e identificadores

• Isómeros SMILES: CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
• PubChem CID: 121304016
• Peso molecular: 602.58

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 26 mg/mL (202.88 mM); Water: Insoluble; Ethanol: Insoluble

Referencias

1. Dong Huijun, Pan Zihang, Jiao Pengtao, Ye Fei, Peng Qi, Yu Yanying, Lai Xinyuan, Li Huan, Guan Zhao, Deng Juan, Shen Tao, Tan Wenjie, Shi Yi, Ding Qiang, Luo Jianyuan, Li Tong, Zhuang Hui, Xiang Kuanhui.  (2025)  Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.  Nature Communications,  16  (1): (1-20).  [PMID:40624080] [10.1038/s41467-025-61655-8]

2. Yun-Lu Xu, Xue-Jian Li, Wei Cai, Wen-Ying Yu, Jing Chen, Qin Lee, Yong-Jun Choi, Fang Wu, Ying-Jun Lou, Hua-Zhong Ying, Chen-Huan Yu, Qiao-Feng Wu.  (2024)  Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39182703] [10.1016/j.jep.2024.118704]

3. Chen Zhu, Kun Fu, Hu Wen, Guangqi Chen, Henggui Zhang.  (2026)  Electrophysiological and Molecular Features of Remdesivir-Induced Cardiac Toxicity in Male and Female Guinea Pigs.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  27  (8): (3685).  [PMID:] [10.3390/ijms27083685]