GRADE & PURITY Moligand™, ≥95%

Synonyms

NSC 12097 | BCBcMAP01_000141 | SMP1_000256 | NCI60_000493 | Z1513803227 | CHEBI:51602 | BRN 0174850 | NSC 12097 | US9216974,Resorufin | 3H-Phenoxazin-3-one, 7-hydroxy- | CCG-36357 | Resorufine | Resorufin, High purity standard | BDBM195591 | EINECS 211-24

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Red fluorescent group standard. It is widely used in enzyme determination system. The absorption and fluorescence of trihalogenase are pH dependent. The absorption transfer to about 480nm, e and fluorescence quantum yield decreased significantly. In the presence of thiols such as DTT and 2-mercaptoethanol, the experimental haloling is unstable.

The experimental halogenase has high extinction coefficient and good chemical and light stability. These properties of trihaloling make it very suitable for the detection of H2O2 by reverse fluorescence method. The fluorescence disappearance of horseradish peroxidase mediated oxidation into non fluorescent derivatives is determined.

Specifications

Sinónimos

NSC 12097 | BCBcMAP01_000141 | SMP1_000256 | NCI60_000493 | Z1513803227 | CHEBI:51602 | BRN 0174850 | NSC 12097 | US9216974, Resorufin | 3H-Phenoxazin-3-one, 7-hydroxy- | CCG-36357 | Resorufine | Resorufin, High purity standard | BDBM195591 | EINECS 211-24

Especificaciones y pureza

Moligand™, ≥95%

Mecanismos bioquímicos y fisiológicos

Stable red fluorophore probe. Widely used in cell labeling and Amplex Red type enzyme assays. It represents the reduced dye formed from Amplex Red reaction or resazurin reductions. Unstable in the presence of thiols such as dithiothreitol (DTT) and 2-merc

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nota

Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504754395
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504754395
• Sonrisas canónicas: C1=CC2=C(C=C1O)OC3=CC(=O)C=CC3=N2
• IUPAC Name: 7-hydroxyphenoxazin-3-one
• InChIKey: HSSLDCABUXLXKM-UHFFFAOYSA-N
• INCHI: 1S/C12H7NO3/c14-7-1-3-9-11(5-7)16-12-6-8(15)2-4-10(12)13-9/h1-6,14H
• Isómeros SMILES: C1=CC2=C(C=C1O)OC3=CC(=O)C=CC3=N2
• PubChem CID: 69462
• Peso molecular: 213.19

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzoxazines
      • Subclass Phenoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzoxazines
• Subclass: Phenoxazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenoxazines
• Alternative Parents: 1-hydroxy-2-unsubstituted benzenoids Heteroaromatic compounds Cyclic ketones Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenoxazine - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Heteroaromatic compound - Cyclic ketone - Oxacycle - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenoxazines. These are polycyclic aromatic compounds containing a phenoxazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a 1,4-oxazine ring.
• External Descriptors: phenoxazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

APP Tclin Amyloid-beta A4 protein (1 Activities)

Discover Target: APP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein (8510 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

Discover Target: CYP1A1

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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Objetivos asociados (no humanos)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Insoluble in water and ether
• Sensibilidad: Light sensitive
• Punto de fusión (°C): >300 °C (lit.)
• Peso molecular: 213.190 g/mol
• XLogP3: 1.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 213.043 Da
• Monoisotopic Mass: 213.043 Da
• Topological Polar Surface Area: 58.900 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 422.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Mengjing Zhao, Huan Zhao, Jiangming Deng, Lianxia Guo, Baojian Wu.  (2019)  Role of the CLOCK protein in liver detoxification.  BRITISH JOURNAL OF PHARMACOLOGY,  176  (24): (4639-4652).  [PMID:31404943] [10.1111/bph.14828]

2. Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng, Jiang Zheng.  (2019)  Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism.  DRUG METABOLISM AND DISPOSITION,  47  (8): (919-927).  [PMID:31147316] [10.1124/dmd.119.086892]

3. Xu Ke, Dong Hui, Wang Zuying, Chen Weitian, Zhou Yan, Cheng Menghao, Du Bingbing, Wei Xiuhua, Zhu Xu, Zhou Yanli, Li Zhaohui, Zhang Yintang, Xu Maotian.  (2025)  Ultrasonic-assisted molecular probe for turn-on electrochemical and fluorescence dual-mode detection of GSH in human serum.  MICROCHIMICA ACTA,  192  (8): (1-12).  [PMID:40610647] [10.1007/s00604-025-07345-0]

4. Weijie Jiang, Xin Guan, Wei Liu, Yunxing Li, Hang Jiang, To Ngai.  (2025)  Rotating Liquid Marble Microreactors for Enhanced Enzymatic Reactions.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202504193]

5. Yi Yang, Licheng Yu, Haiyang Wang, Liang He, Pengli Bai, Xiwen He, Langxing Chen, Yukui Zhang.  (2026)  Natural Cell-Inspired Integration of Redox Reactant Molecules in Hierarchical MOFs Harvested for Reaction Pathway-Regulated Glycoprotein Assay.  ANALYTICAL CHEMISTRY,      [PMID:41540912] [10.1021/acs.analchem.5c05891]