RF9 hydrochloride - 10mM in DMSO , CAS No.R661629(DMSO)

CAS: R661629(DMSO) Cat. No.: R661629 Peso molecular: 519.08

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively.

IC50& Target:hNPFF1R 58 nM (Ki) hNPFF2R 75 nM (Ki)

In Vitro:RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:RF9 (0.1mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoke

Biological Activity:RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively .

Specifications

Especificaciones y pureza

10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Sonrisas canónicas: NC(C(CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)CC(C[C@@H]4C3)C2)=O)=O)=O.Cl
• Peso molecular: 519.08