Rilematovir - 10mM in DMSO , Fusion glycoprotein F0 inhibitor, CAS No.1383450-81-4, Fusion glycoprotein F0 inhibitor

CAS: 1383450-81-4 Cat. No.: R655660 Peso molecular: 500.92 PubChem CID: 118892432

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research.

In Vitro

Rilematovir is a small-molecule respiratory syncytial virus (RSV) fusion inhibitor currently under clinical evaluation in infants hospitalized for RSV infection. Rilematovir binds to RSV F protein in its prefusion conformation. Rilematovir displays very potent antiviral activity and low cytotoxicity. In addition to its activity against the RSV A2 strain, Rilematovir is also highly active against a number of RSV strains from both A and B subtypes. The EC 50 in an RSV infection assay using HeLa cells is 460 pM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog, efficiently inhibits established acute lower respiratory tract infection in the animals, even when treatment is delayed until external signs of respiratory syncytial virus illness have become visible . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Fusion protein

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Fusion glycoprotein F0 inhibitor

Propiedades del producto

• ALogP: 2.9

Nombres e identificadores

• Isómeros SMILES: CS(=O)(=O)CCCN1C2=C(C=C(C=C2)Cl)C=C1CN3C4=C(C=CN=C4)N(C3=O)CC(F)(F)F
• CAS alternativo: 1383450-81-4
• PubChem CID: 118892432
• Términos de entrada MeSH: JNJ-53718678
• Peso molecular: 500.92