RIPK1-IN-7 - 10mM in DMSO , Inhibitor of AXL receptor tyrosine kinase;Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1;Inhibitor of fms related receptor tyrosine kinase 4;Inhib, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of MER proto-oncogene;
RIPK1-IN-7 - 10mM in DMSO , Inhibitor of AXL receptor tyrosine kinase;Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1;Inhibitor of fms related receptor tyrosine kinase 4;Inhib, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of MER proto-oncogene;
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K d of 4 nM and an enzymatic IC 50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model
In Vitro
RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM. RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K d of 4 nM and an enzymatic IC 50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
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Tipo de acción
INHIBITOR
Mecanismo de acción
Inhibitor of AXL receptor tyrosine kinase;Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of MER proto-oncogene;
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