Risedronate Sodium - ≥98% , Farnesyl diphosphate synthase inhibitor, CAS No.115436-72-1, Farnesyl diphosphate synthase inhibitor

CAS: 115436-72-1 Cat. No.: R129954 Peso molecular: 305.09 Número EC: 601-362-8 PubChem CID: 4194514

GRADE & PURITY ≥98%

Synonyms

AC-20120 | Acrel | D00942 | H11438 | Sodium trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate | DRFDPXKCEWYIAW-UHFFFAOYSA-M | Risedronate (sodium) | Risedronate sodium 2.5-hydrate, European Pharmacopoeia (EP) Reference Standard | Risedronate so

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Risedronate Sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.
A pyridinyl biphosphonate.

Specifications

Sinónimos

AC-20120 | Acrel | D00942 | H11438 | Sodium trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate | DRFDPXKCEWYIAW-UHFFFAOYSA-M | Risedronate (sodium) | Risedronate sodium 2.5-hydrate, European Pharmacopoeia (EP) Reference Standard | Risedronate so

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption. Risedronate sodium is an inhibitor of FDPS.Osteoclast-mediated bone resorption inhibitor. Promotes osteoblast differentiation and reduces osteocyte apoptos

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Farnesyl diphosphate synthase inhibitor

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504762908
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504762908
• Sonrisas canónicas: C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
• IUPAC Name: sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate
• InChIKey: DRFDPXKCEWYIAW-UHFFFAOYSA-M
• INCHI: 1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
• Isómeros SMILES: C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
• WGK Alemania: 3
• RTECS: SZ8567200
• CAS alternativo: 105462-24-6，329003-65-8
• PubChem CID: 4194514
• Peso molecular: 305.09

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Organic phosphonic acids and derivatives
      • Subclass Bisphosphonates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Organic phosphonic acids and derivatives
• Subclass: Bisphosphonates
• Intermediate Tree Nodes: Not available
• Direct Parent: Bisphosphonates
• Alternative Parents: Pyridines and derivatives Organic phosphonic acids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organonitrogen compounds Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Bisphosphonate - Pyridine - Organophosphonic acid - Heteroaromatic compound - Organoheterocyclic compound - Organic alkali metal salt - Azacycle - Organic nitrogen compound - Organic sodium salt - Organic salt - Organic zwitterion - Organopnictogen compound - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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SARS-CoV-2 (38078 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO Water 2 mg/mL Ethanol；Soluble in water, insoluble in ethanol
• Sensibilidad: Moisture and heat sensitive
• Peso molecular: 305.090 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 304.983 Da
• Monoisotopic Mass: 304.983 Da
• Topological Polar Surface Area: 151.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 375.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Cong Wang, Wenting Liu, Yong Huang, Lin Zheng, Lili Wang, Ruixi Li, Chang Yang.  (2025)  Mitigating gastrointestinal side effects of risedronate sodium: A study on Bletilla striata polysaccharide microneedle patches.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40288506] [10.1016/j.ijpharm.2025.125609]