Rosiglitazone (BRL-49653) maleate - 10mM in DMSO , Peroxisome proliferator-activated receptor gamma agonist, CAS No.155141-29-0, Peroxisome proliferator-activated receptor gamma agonist

CAS: 155141-29-0 Cat. No.: R407920 Peso molecular: 473.5 Número EC: 642-163-6 PubChem CID: 5281055

GRADE & PURITY 10mM in DMSO

Synonyms

5-​[[4-​[2-​(methyl-​2-​pyridinylamino)​ethoxy]​phenyl]​methyl]​-2,​4-​thiazolidinedione,(2Z)​-​2-​butenedioate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Rosiglitazone maleate (BRL 49653), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of theperoxisome proliferator-activated receptor-γ (PPAR-γ)with IC50 of 42 nM. Rosiglitazone maleate also modulat
In vitro

Rosiglitazone is an insulin-sensitising agent of the thiazolidinedione class of oral antihyperglycaemic drugs. Rosiglitazone exhibits insulin-sensitising activity 60- to 200-fold higher than that of troglitazone, englitazone, or piogliazone in rodent models of insulin ressitance. Rosiglitazone reduces hyperglycaemia by improving insulin sensitivity in adipose tissue, the liver and skeletal muscle tissue. Such insulin sensitisation may be partly attributable to the effects of Rosiglitazone on the expression of molecules involved in the insulin signalling cascade. In adipose tissue, Rosiglitazone-mediated PPARγ stimulation promotes adipocyte differentiation. Rosiglitazone may also promote the uptake of free fatty acids in adipose tissue, thus reducing systemic free fatty acid levels. The insulin sensitivity of the liver and peripheral tissues may be modulated indirectly by Rosiglitazone-mediated changes in levels of fatty acid or adipocyte-derived factors, such as adiponectin and TNFα. Rosiglitazone may also be involved in modulating the expression of adiponectin receptors in some tissues, which may be relevant to some aspects of insulin sensitisation.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

5-​[[4-​[2-​(methyl-​2-​pyridinylamino)​ethoxy]​phenyl]​methyl]​-2, ​4-​thiazolidinedione, (2Z)​-​2-​butenedioate (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Rosiglitazone maleate (BRL 49653), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modul

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

AGONIST

Mecanismo de acción

Peroxisome proliferator-activated receptor gamma agonist

Nombres e identificadores

• Isómeros SMILES: CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=C\C(=O)O)\C(=O)O
• PubChem CID: 5281055
• Peso molecular: 473.5

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 29 mg/mL (199.77 mM); Water: 29 mg/mL (199.77 mM); Ethanol: 29 mg/mL