(S,R,S)-AHPC-PEG₃-Alkyne - ≥95% , CAS No.2374122-30-0

CAS: 2374122-30-0 Cat. No.: S463452 Peso molecular: 628.78 PubChem CID: 145710072

GRADE & PURITY ≥95%

Synonyms

Protein degrader building block for PROTAC research, VH032 conjugate, Crosslinker–E3 Ligase ligand conjugate, (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Description

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinónimos

Protein degrader building block for PROTAC research, VH032 conjugate, Crosslinker–E3 Ligase ligand conjugate, (2S, 4R)-1-((S)-2-(tert-Butyl)-4-oxo-7, 10, 13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl

Especificaciones y pureza

≥95%

Información jurídica

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥95%

Nombres e identificadores

• Sonrisas canónicas: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCOCC#C)O
• IUPAC Name: (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoylamino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChIKey: VAUAWSOCVFFOPH-UWPQIUOOSA-N
• INCHI: 1S/C32H44N4O7S/c1-6-12-41-14-16-43-17-15-42-13-11-27(38)35-29(32(3,4)5)31(40)36-20-25(37)18-26(36)30(39)33-19-23-7-9-24(10-8-23)28-22(2)34-21-44-28/h1,7-10,21,25-26,29,37H,11-20H2,2-5H3,(H,33,39)(H,35,38)/t25-,26+,29-/m1/s1
• PubChem CID: 145710072
• Peso molecular: 628.78

Propiedades químicas y físicas

• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable