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(S)-Willardiine - ≥99% , CAS No.21416-43-3

CAS: 21416-43-3 Cat. No.: W646211 Peso molecular: 199.166 PubChem CID: 440053
COA
(S)-Willardiine - ≥99% CAS No(21416-43-3) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY ≥99%
Synonyms
3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)alanine | S(-)-Willardiine | SR-01000039436-1 | SCHEMBL13319907 | (2S)-2-amino-3-(2,4-dioxopyrimidin-1-yl)propanoic acid | CCG-205293 | 3-(Uracil-1-yl)-L-alanine | SCHEMBL401191 | 2-amino-3-(2,4-dioxo-3,4-dihydro
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
10mg
W646211-10mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

145,90US$

218,90US$
Guardar 73,00 US$ (33.35%)
50mg
W646211-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

640,90US$

961,90US$
Guardar 321,00 US$ (33.37%)
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas
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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50)Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50%.in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists

Form:Solid

IC50& Target:Kainate Receptor

Specifications

Sinónimos
3-(2, 4-dioxo-3, 4-dihydropyrimidin-1(2H)-yl)alanine | S(-)-Willardiine | SR-01000039436-1 | SCHEMBL13319907 | (2S)-2-amino-3-(2, 4-dioxopyrimidin-1-yl)propanoic acid | CCG-205293 | 3-(Uracil-1-yl)-L-alanine | SCHEMBL401191 | 2-amino-3-(2, 4-dioxo-3, 4-dihydro
Especificaciones y pureza
≥99%
Mecanismos bioquímicos y fisiológicos
(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.\nIC50 value: 44.8 uM(EC50) \nTarget: AMPA/kainate receptor agonist\nin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, p
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
AGONIST
Pureza
≥99%
Nombres e identificadores
Sonrisas canónicasC1=CN(C(=O)NC1=O)CC(C(=O)O)N
IUPAC Name(2S)-2-amino-3-(2,4-dioxopyrimidin-1-yl)propanoic acid
InChIKeyFACUYWPMDKTVFU-BYPYZUCNSA-N
INCHI1S/C7H9N3O4/c8-4(6(12)13)3-10-2-1-5(11)9-7(10)14/h1-2,4H,3,8H2,(H,12,13)(H,9,11,14)/t4-/m0/s1
Isómeros SMILES C1=CN(C(=O)NC1=O)C[C@@H](C(=O)O)N
PubChem CID 440053
Peso molecular 199.166

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClaseCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct ParentL-alpha-amino acids
Alternative Parents Pyrimidones  Hydropyrimidines  Vinylogous amides  Heteroaromatic compounds  Ureas  Lactams  Amino acids  Monocarboxylic acids and derivatives  Carboxylic acids  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents L-alpha-amino acid - Pyrimidone - Hydropyrimidine - Pyrimidine - Vinylogous amide - Heteroaromatic compound - Lactam - Urea - Amino acid - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Carboxylic acid - Azacycle - Carbonyl group - Amine - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors non-proteinogenic L-alpha-amino acid - L-alanine derivative
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
GRIA4 Tclin Glutamate receptor 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA2 Tclin Glutamate receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA1 Tclin Glutamate receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FOLH1 Tclin Glutamate carboxypeptidase II (711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA3 Tclin Glutamate receptor ionotropic, AMPA 3 (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA2 Tclin Glutamate receptor ionotropic, AMPA 2 (847 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIK5 Tclin Glutamate receptor ionotropic kainate 5 (45 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SolubilidadDMSO : <1 mg/mL (ultrasonic) (insoluble or slightly soluble)
Peso molecular199.160 g/mol
XLogP3-4.400
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass199.059 Da
Monoisotopic Mass199.059 Da
Topological Polar Surface Area113.000 Ų
Heavy Atom Count14
Formal Charge0
Complexity312.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
Reseñas

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