Sacubitril/valsartan (LCZ696) - 10mM in DMSO , CAS No.936623-90-4

CAS: 936623-90-4 Cat. No.: S408027 Peso molecular: 915.98 Número EC: 810-144-3

GRADE & PURITY 10mM in DMSO

Synonyms

Sacubitril, Valsartan | N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2?)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and h
In vitro

In vivo

In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Sacubitril, Valsartan | N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1, 1'-biphenyl]-4-yl]methyl]-L-valine, compd. with α-ethyl (αR, γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1, 1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2?)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Peso molecular: 915.98

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro