Salvianolic acid B - analytical standard, ≥98% , CAS No.115939-25-8

CAS: 115939-25-8 Cat. No.: S101148 Peso molecular: 718.62 PubChem CID: 11629084

GRADE & PURITY Analytical standard, ≥98%

Synonyms

[2R-[2a,3b-(R*),4[E(R*)]]]-3-Benzofurancarboxylic acid 4-[3-[1-carboxy-2-(3,4-dihydroxy-phenyl) ethoxy]-3-oxo-1-propenyl]-2-(3,4-dihydrophenyl)-2,3-dihydro-7-hydroxyl-3-[1-carboxy-2-(3,4-dihydroxyphenyl) ethyl] ester

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Salvianolic acid B, also known as Lithospermic acid B, is a polyphenol and a member of catechols. This bioactive natural compound is commonly found in plants such as Salvia Sp., Isodon rubescens, Mentha Sp., Canna indica, and Angelica keiskei. Existing research suggests that this plant-derived natural product possesses a range of biological properties, including anticancer, anti-inflammatory, hepatoprotective, cardioprotective and neuroprotective activities.

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

According to the existing research, Salvianolic acid B plays potential role in modulating inflammation, cell signaling, and immune responses by inhibiting the expression of COX, ERK, TNF-α, NO.
Salvianolic acid B has anti-obesity, antiviral (COVID-19) and free radical scavenging activity.

Specifications

Sinónimos

[2R-[2a, 3b-(R*), 4[E(R*)]]]-3-Benzofurancarboxylic acid 4-[3-[1-carboxy-2-(3, 4-dihydroxy-phenyl) ethoxy]-3-oxo-1-propenyl]-2-(3, 4-dihydrophenyl)-2, 3-dihydro-7-hydroxyl-3-[1-carboxy-2-(3, 4-dihydroxyphenyl) ethyl] ester

Especificaciones y pureza

analytical standard, ≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Analytical standard

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C3C(C(OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)C(=O)OC(CC5=CC(=C(C=C5)O)O)C(=O)O)O)O
• IUPAC Name: (2R)-2-[(E)-3-[(2R,3R)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid
• InChIKey: SNKFFCBZYFGCQN-PDVBOLEISA-N
• INCHI: 1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31-,32+/m1/s1
• Isómeros SMILES: C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=C3[C@H]([C@@H](OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)C(=O)O[C@H](CC5=CC(=C(C=C5)O)O)C(=O)O)O)O
• PubChem CID: 11629084
• Peso molecular: 718.62

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Clase 2-arylbenzofuran flavonoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Clase: 2-arylbenzofuran flavonoids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: 2-arylbenzofuran flavonoids
• Alternative Parents: Tetracarboxylic acids and derivatives Coumaric acids and derivatives Phenylpropanoic acids Coumarans Styrenes Catechols 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Alkyl aryl ethers Fatty acid esters Enoate esters Oxacyclic compounds Carboxylic acids Hydrocarbon derivatives Carbonyl compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 2-arylbenzofuran flavonoid - Tetracarboxylic acid or derivatives - Coumaric acid or derivatives - 3-phenylpropanoic-acid - Coumaran - Catechol - Styrene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Fatty acid ester - 1-hydroxy-4-unsubstituted benzenoid - Alkyl aryl ether - Fatty acyl - Benzenoid - Monocyclic benzene moiety - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Carboxylic acid ester - Organoheterocyclic compound - Oxacycle - Carboxylic acid derivative - Ether - Carboxylic acid - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nqo1 NAD(P)H dehydrogenase [quinone] 1 (1058 Activities)

Discover Target: Nqo1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Light Sensitive
• Peso molecular: 718.600 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 14
• Exact Mass: 718.153 Da
• Monoisotopic Mass: 718.153 Da
• Topological Polar Surface Area: 278.000 Ų
• Heavy Atom Count: 52
• Formal Charge: 0
• Complexity: 1290.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Referencias

1. Ren Hui, Zhang Zhen, Lu KaiLun, Shen YuanYuan, He ChaoLiang, Chen XueSi.  (2023)  Injectable chitosan hydrogels loaded with antioxidant agent as first-aid dressings for second-degree burn wounds.  Science China-Technological Sciences,      [PMID:] [10.1007/s11431-023-2509-4]

2. Jingtong Xia, Minhua Qian, Jiahao Zhou, Zhaoyan Wang, Hongli Li, Lei Zhou, Qiaosheng Pu.  (2022)  Integrated strategy of derivatization and separation for sensitive analysis of salvianolic acids using capillary electrophoresis with laser-induced fluorescence detection.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:36334567] [10.1016/j.chroma.2022.463607]

3. Bo Lu, Jianhua Li, MingTai Gui, Lei Yao, Mingsong Fan, Xunjie Zhou, Deyu Fu.  (2022)  Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.  PHARMACEUTICAL BIOLOGY,      [PMID:35968584] [10.1080/13880209.2022.2096644]

4. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai.  (2022)  A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza.  METABOLIC ENGINEERING,      [PMID:35934177] [10.1016/j.ymben.2022.08.002]

5. Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen.  (2020)  Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling.  Annals of Hepatology,      [PMID:32980439] [10.1016/j.aohep.2020.07.013]

6. Qing-Hong Du, Chu-Jun Zhang, Wei-Hong Li, Yan Mu, Ya Xu, Scott Lowe, Lin Han, Xue Yu, Shu-Yan Wang, Yu Li, Jian Li.  (2020)  Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation.  WORLD JOURNAL OF GASTROENTEROLOGY,      [PMID:32550756] [10.3748/wjg.v26.i21.2810]

7. Ying Bian, Juan Xiang.  (2020)  Salvianolic acid B promotes the osteogenic differentiation of human periodontal ligament cells through Wnt/β-catenin signaling pathway.  ARCHIVES OF ORAL BIOLOGY,      [PMID:32179247] [10.1016/j.archoralbio.2020.104693]

8. Feng-Qin Wang, Qian Zhang, Chun-Hong Li, Yin-Zhen Wang, Yuan-Jia Hu, Qi-Hui Zhang, Zhi-Ning Xia, Feng-Qing Yang.  (2015)  Evaluation of affinity interaction between small molecules and platelets by open tubular affinity capillary electrochromatography.  ELECTROPHORESIS,      [PMID:26541914] [10.1002/elps.201500414]

9. Xin Peng, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He.  (2015)  Elucidating the Influence of Gold Nanoparticles on the Binding of Salvianolic Acid B and Rosmarinic Acid to Bovine Serum Albumin.  PLoS One,  10  (4): (e0118274).  [PMID:25861047] [10.1371/journal.pone.0118274]

10. Yong Jiang, Wenjun Ji, Ying Lu, Qin Wang, Linwei Chen.  (2025)  Integrating Plasma Metabolomics, Network Pharmacology, and Experimental Validation to Investigate the Action Mechanism of Qiangxin Lishui Prescription in Chronic Heart Failure.  BIOMEDICAL CHROMATOGRAPHY,  39  (2): (e6065).  [PMID:39748248] [10.1002/bmc.6065]

11. Jing Wen, Shue Jin, Xue Luo, Chunhong Chen, Huan Liu, Yubao Li, Jidong Li.  (2025)  Functionalized gelatin/poly(l-lactide-co-ε-caprolactone) fibrous membrane promotes scarless wound healing by modulating inflammation and reducing fibrosis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40054818] [10.1016/j.ijbiomac.2025.141785]