Saroglitazar magnesium - ≥98% , CAS No.1639792-20-3

CAS: 1639792-20-3 Cat. No.: S648124 Peso molecular: 901.42 PubChem CID: 121000421

GRADE & PURITY ≥98%

Synonyms

K8V5DLS63R | 1639792-20-3 | Q27282102 | EX-A5519 | MAGNESIUM, BIS((.ALPHA.S)-.ALPHA.-(ETHOXY-.KAPPA.O)-4-(2-(2-METHYL-5-(4-(METHYLTHIO)PHENYL)-1H-PYRROL-1-YL)ETHOXY)BENZENEPROPANOATO-.KAPPA.O)-, (T-4)- | Saroglitazar magnesium | magnesium;(2S)-2-ethoxy-3-

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor ( PPAR ) agonist with predominant PPARα and moderate PPARγ activity with EC 50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

In Vivo

In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED 50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:PPARα 0.65 pM (EC 50 , HepG2 cell) PPARγ 3 nM (EC 50 , HepG2 cell)

Specifications

Sinónimos

K8V5DLS63R | 1639792-20-3 | Q27282102 | EX-A5519 | MAGNESIUM, BIS((.ALPHA.S)-.ALPHA.-(ETHOXY-.KAPPA.O)-4-(2-(2-METHYL-5-(4-(METHYLTHIO)PHENYL)-1H-PYRROL-1-YL)ETHOXY)BENZENEPROPANOATO-.KAPPA.O)-, (T-4)- | Saroglitazar magnesium | magnesium;(2S)-2-ethoxy-3-

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor ( PPAR ) agonist with predominant PPARα and moderate PPARγ activity with EC 50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CCOC(CC1=CC=C(C=C1)OCCN2C(=CC=C2C3=CC=C(C=C3)SC)C)C(=O)[O-].CCOC(CC1=CC=C(C=C1)OCCN2C(=CC=C2C3=CC=C(C=C3)SC)C)C(=O)[O-].[Mg+2]
• IUPAC Name: magnesium;(2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoate
• InChIKey: UJYFZCVPOSZDMK-YPPDDXJESA-L
• INCHI: 1S/2C25H29NO4S.Mg/c2*1-4-29-24(25(27)28)17-19-6-10-21(11-7-19)30-16-15-26-18(2)5-14-23(26)20-8-12-22(31-3)13-9-20;/h2*5-14,24H,4,15-17H2,1-3H3,(H,27,28);/q;;+2/p-2/t2*24-;/m00./s1
• Isómeros SMILES: CCO[C@@H](CC1=CC=C(C=C1)OCCN2C(=CC=C2C3=CC=C(C=C3)SC)C)C(=O)[O-].CCO[C@@H](CC1=CC=C(C=C1)OCCN2C(=CC=C2C3=CC=C(C=C3)SC)C)C(=O)[O-].[Mg+2]
• CAS alternativo: 1639792-20-3
• PubChem CID: 121000421
• Términos de entrada MeSH: (2S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylsulfanyl)phenyl)-1H-pyrrol-1-yl(ethoxy)phenyl)propanoic acid;(2S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylsulfanyl)phenyl)-1H-pyrrol-1-yl(ethoxy)phenyl)propanoic acid magnesium salt (2:1);alpha-ethoxy-4-(2-(2-met
• Peso molecular: 901.42

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyrroles
      • Subclass Substituted pyrroles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyrroles
• Subclass: Substituted pyrroles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrroles
• Alternative Parents: Thiophenol ethers Phenoxy compounds Phenol ethers Alkylarylthioethers Alkyl aryl ethers Dicarboxylic acids and derivatives Heteroaromatic compounds Trialkylamines Thioenol ethers Carboxylic acid salts Amino acids and derivatives Sulfenyl compounds Oxacyclic compounds Organic metal salts Metalloheterocyclic compounds Enamines Azacyclic compounds Organopnictogen compounds Organic zwitterions Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 2-phenylpyrrole - Phenoxy compound - Aryl thioether - Thiophenol ether - Phenol ether - Alkylarylthioether - Alkyl aryl ether - Benzenoid - Dicarboxylic acid or derivatives - Monocyclic benzene moiety - Heteroaromatic compound - Tertiary aliphatic amine - Thioenolether - Tertiary amine - Carboxylic acid salt - Amino acid or derivatives - Oxacycle - Azacycle - Organic metal salt - Sulfenyl compound - Thioether - Metalloheterocycle - Ether - Enamine - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organic zwitterion - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylpyrroles. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMSO : 125 mg/mL (138.67 mM; Need ultrasonic)