Sarolaner - ≥99% , CAS No.1398609-39-6

CAS: 1398609-39-6 Cat. No.: S647577 Peso molecular: 581.36 Número EC: 806-747-6 PubChem CID: 73169092

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide . Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC 80 value of 0.3 μg/mL against C. felis and a LC 100 value of 0.003 μg/mL against O. turicata

In Vitro

Sarolaner (450 nM-1 mM; 5 min) inhibits CfRDL-A285 and CfRDL-S285 receptors with γ-Aminobutyric acid (GABA)-induced currents. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: CHO-K1 cell lines Concentration: 450 nM-1 mM Incubation Time: 5 min Result: Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC 50 s of 135 and 136 nM, respectively.

In Vivo

Sarolaner (2.5 mg/kg; p.o. once) shows 100% efficacious against R. sanguineus and D. reticulatus . Sarolaner (1.25- 5 mg/kg; p.o. once) effectively against I. ricinus . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Dog infested with R. sanguineus and D. reticulatus Dosage: 2.5 mg/kg Administration: Oral gavage; 2.5 mg/kg once Result: Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy against D. reticulatus . Animal Model: Dog infested with I. ricinus Dosage: 1.25, 2.5 and 5 mg/kg Administration: Oral gavage; 1.25, 2.5 and 5 mg/kg once Result: Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.

Form:Solid

IC50& Target:LC80: 0.3μg/mL ( C. felis ), LC100: 0.003 μg/mL ( O. turicata ), IC50: 135 nM (CfRDL-A285), 136 nM (CfRDL-S285)

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide . Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC 80 value of 0.3 μg/mL against C. felis and a LC 100 value of 0.003 μg/mL

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F
• Isómeros SMILES: CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F
• PubChem CID: 73169092
• Peso molecular: 581.36

Propiedades químicas y físicas

• Solubilidad: DMSO : 300 mg/mL (516.03 mM; Need ultrasonic)
• Peso molecular: 581.400 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 4
• Exact Mass: 580.025 Da
• Monoisotopic Mass: 580.025 Da
• Topological Polar Surface Area: 93.700 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 1050.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1