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SBI-581 - 10mM in DMSO , CAS No.S661711(DMSO)
Disponible para pedir
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC 50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinet
IC50& Target:IC 50 : 42 nM (TAO3), 237 nM (MEKK3)
In Vitro:SBI-581 shows moderate selectivity (> 5-10x) against the majority of a broad panel of kinases. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:SBI-581 (10mg/kg, IP, once) displays reasonable pharmacokinetics (t 1/2 =1.5 hr; AUC= 1202 hr*ng/mL; Cmax= ~2 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological Activity:SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC 50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinet
Specifications
Especificaciones y pureza
10mM in DMSO
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
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Nombres e identificadores
| Sonrisas canónicas | O=C1/C(C2=C(C=CC=C2C#CC3(O)CCNCC3)N1)=C\\C4=CC5=C(N4)C=CC=C5 |
|---|---|
| Peso molecular | 383.44 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Calculadoras de soluciones
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