Se-(Methyl)seleno-L-cysteine - ≥98%(HPLC)(T) , CAS No.26046-90-2

CAS: 26046-90-2 Cat. No.: S161277 Peso molecular: 182.08 Número EC: 684-218-7 PubChem CID: 147004

GRADE & PURITY ≥98%(HPLC)(T)

Synonyms

methyl-L-selenocysteine | (2R)-2-amino-3-methylselanylpropanoic acid | 2-Amino-3-methylselenyl propionic acid | DB12697 | Lopac0_000799 | Methylseleno-L-cysteine | Se-(Methyl)selenocysteine hydrochloride | Se-Methyl-L-selenocysteine | (R)-2-Amino-3-(methy

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

methyl-L-selenocysteine | (2R)-2-amino-3-methylselanylpropanoic acid | 2-Amino-3-methylselenyl propionic acid | DB12697 | Lopac0_000799 | Methylseleno-L-cysteine | Se-(Methyl)selenocysteine hydrochloride | Se-Methyl-L-selenocysteine | (R)-2-Amino-3-(methy

Especificaciones y pureza

≥98%(HPLC)(T)

Mecanismos bioquímicos y fisiológicos

Seleno-amino acid. Induces apoptosis through caspase activation. Inhibits DMBA-induced mammary tumors. Potentiates antitumour activity and selectivity of chemotherapeutic agents. Shows chemopreventive effects in vivo.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%(HPLC)(T)

Nombres e identificadores

• Pubchem Sid: 504757306
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757306
• Sonrisas canónicas: C[Se]CC(C(=O)O)N
• IUPAC Name: (2R)-2-amino-3-methylselanylpropanoic acid
• InChIKey: XDSSPSLGNGIIHP-VKHMYHEASA-N
• INCHI: 1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
• Isómeros SMILES: C[Se]C[C@@H](C(=O)O)N
• CAS alternativo: 863394-07-4
• PubChem CID: 147004
• Peso molecular: 182.08

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Amino acids Selenoethers Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Selenoether - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary amine - Organoselenium compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Primary aliphatic amine - Organic nitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: non-proteinogenic L-alpha-amino acid - Se-methylselenocysteine - L-selenocysteine derivative

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KYAT1 Tbio Kynurenine--oxoglutarate transaminase I (96 Activities)

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A-375 (9258 Activities)

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Hs68 (138 Activities)

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MCF7 (126967 Activities)

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HEK293 (82097 Activities)

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SW-620 (52400 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

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Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Mycolicibacterium smegmatis (8003 Activities)

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V79 (1637 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

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Mecanismos de acción

Propiedades químicas y físicas

• Punto de fusión (°C): 177 °C(dec.)
• Peso molecular: 182.090 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 182.98 Da
• Monoisotopic Mass: 182.98 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 86.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3

Referencias

1. Furong Wang, Min Yan, Ting Zhang, Zhen Tian, Xinxin Niu, Zimeng Guo, Xian Wang, Xiaoben Li, Wei Song, Yan'e Luo, Yahong Yuan, Tianli Yue.  (2024)  Insight into sodium selenite-induced metabolic reprogramming in response to main seleno-amino acid enrichment in Saccharomyces cerevisiae using metabolomics.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.103997]

2. Xiao-Xia Zhou, Quanzhi Xiao, Kena Zhang, Yan Gao, Jie Zhang, Liping Fang, Bing Yan, Fangbai Li.  (2024)  Quantitatively Tracking the Speciation and Dynamics of Selenium Nanoparticles in Rice Plants.  ANALYTICAL CHEMISTRY,      [PMID:39361821] [10.1021/acs.analchem.4c04032]