Secoisolariciresinol diglucoside - 10mM in Water , CAS No.257930-74-8

CAS: 257930-74-8 Cat. No.: S654841 Peso molecular: 686.70 PubChem CID: 72189390

GRADE & PURITY 10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.

In Vitro

Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals. Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Hand feeding mice (10 weeks old, male) are injected with TNFαDosage: 4 mg/mouse Administration: P.o. 2 h before i.c. administration of TNFα Result: Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

Specifications

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Secoisolariciresinol diglucoside ((S, S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects [1

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: COC1=C(C=CC(=C1)C[C@H](CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)[C@H](CC3=CC(=C(C=C3)O)OC)CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
• PubChem CID: 72189390
• Peso molecular: 686.70