SET 2 - Moligand™, ≥98%(HPLC) , Channel blocker of TRPV2, CAS No.2313525-20-9, Channel blocker of TRPV2

CAS: 2313525-20-9 Cat. No.: S287626 Peso molecular: 402.44 PubChem CID: 155541857

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

TRPV2 antagonist SET2 | N-(Furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide | AKOS040755628 | HY-132222 | DTXSID101336558 | GTPL12547 | 2313525-20-9 | N-(Furan-2-ylmethyl)-3-(4-(methyl(propyl)amino)-6-(trifl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

TRPV2 antagonist SET2 | N-(Furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide | AKOS040755628 | HY-132222 | DTXSID101336558 | GTPL12547 | 2313525-20-9 | N-(Furan-2-ylmethyl)-3-(4-(methyl(propyl)amino)-6-(trifl

Especificaciones y pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50= 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migrationin vitro.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

CHANNEL BLOCKER

Mecanismo de acción

Channel blocker of TRPV2

Pureza

≥98%(HPLC)

Nombres e identificadores

• Pubchem Sid: 488203091
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488203091
• Sonrisas canónicas: CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2
• IUPAC Name: N-(furan-2-ylmethyl)-3-[4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
• InChIKey: LZHSWRWIMQRTOP-UHFFFAOYSA-N
• INCHI: 1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)
• Isómeros SMILES: CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2
• PubChem CID: 155541857
• Peso molecular: 402.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organosulfur compounds
    • Clase Thioethers
      • Subclass Aryl thioethers

• Kingdom: Organic compounds
• Superclass: Organosulfur compounds
• Clase: Thioethers
• Subclass: Aryl thioethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Aryl thioethers
• Alternative Parents: Dialkylarylamines Aminopyrimidines and derivatives Alkylarylthioethers Imidolactams Heteroaromatic compounds Furans Amino acids and derivatives Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Carboxylic acid amides Carboximidamides Azacyclic compounds Amidines Organopnictogen compounds Organooxygen compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aryl thioether - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Alkylarylthioether - Aminopyrimidine - Imidolactam - Pyrimidine - Heteroaromatic compound - Furan - Tertiary amine - Carboxamide group - Amino acid or derivatives - Oxacycle - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Sulfenyl compound - Carboximidamide - Carboxylic acid derivative - Amidine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as aryl thioethers. These are organosulfur compounds containing a thioether group that is substituted by an aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

TRPV2 Tchem Transient receptor potential cation channel subfamily V member 2 (0 Activities)

Discover Target: TRPV2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (774 Activities)

Discover Target: TRPV4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (542 Activities)

Discover Target: TRPV3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

Discover Target: Trpv2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpv1 Transient receptor potential cation channel subfamily V member 1 (45 Activities)

Discover Target: Trpv1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 40.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.12, Max Conc. mM: 50