SHP394 - 10mM in DMSO , CAS No.2055757-40-7

CAS: 2055757-40-7 Cat. No.: S654504 Peso molecular: 470.51 PubChem CID: 124150499

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

SHP394 is an orally active, selective and allosteric inhibitor of SHP2 , with an IC 50 of 23 nM

In Vitro

SHP394 inhibits Caco-2 cells proliferation with the IC 50 of 297 nM. SHP394 exhibits antiproliferation activity against the Detroit-562 pharyngeal carcinoma cell line in vitro (IC 50 = 1.38 μM). SHP394 decreases p-ERK with an IC 50 of 18 nM KYSE520 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SHP394 (20-80 mg/kg; oral gavage; twice daily) dose-dependent reduces tumor volume . SHP394 (80 mg/kg; oral gavage; twice daily) causes tumor 34% regression and reduces mouse host bodyweight after dosing for 14 days . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-week old female athymic NU/NU mice were inoculated subcutaneously with Detroit-562 pharyngeal carcinoma cells . Dosage: 20, 40, and 80 mg/kg Administration: Oral gavage; twice daily Result: Demonstrated a clear dose-dependent reduction in tumor volume.

IC50& Target:IC50: 23 nM (SHP2)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

SHP394 is an orally active, selective and allosteric inhibitor of SHP2 , with an IC 50 of 23 nM.

Condiciones de almacenamiento de almacenamiento

Argon charged, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: C[C@H]1[C@H](C2(CCN(CC2)C3=NC(=C(C(=O)N3C)SC4=C(N=CC=C4)C(F)(F)F)N)CO1)N
• PubChem CID: 124150499
• Peso molecular: 470.51

Objetivos asociados (humanos)

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 (2 Activities)

Discover Target: PTPN11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)