10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
In vitro
Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. Silymarin can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties. sup>[3]
In vivo
LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.) sup>[4]
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:
| Isómeros SMILES | COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O |
|---|---|
| PubChem CID | 5213 |
| Peso molecular | 482.44 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de inflamación (°C) | 274.4℃ |
|---|---|
| Punto de ebullición (°C) | 793℃ at 760 mmHg |
| 1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2023) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, [PMID:38143010] [10.1016/j.jsbmb.2023.106450] |
| 2. Yuxu Chen, Zhiye Zhao, Shancheng Guo, Yaxian Li, Haiaolong Yin, Lei Tian, Guiguang Cheng, Ye Li. (2023) Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice. Nutrients, 15 (19): (4176). [PMID:37836459] [10.3390/nu15194176] |
| 3. Lu Wang, Xiaohui Wang, Lina Kong, Shuyuan Wang, Kai Huang, Jingjing Wu, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Meng. (2021) Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:34555641] [10.1016/j.intimp.2021.108159] |
| 4. Xiaohui Wang, Lu Wang, Renchao Dong, Kai Huang, Changyuan Wang, Jiangning Gu, Haifeng Luo, Kexin Liu, Jingjing Wu, Huijun Sun, Qiang Meng. (2021) Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice. PHYTOMEDICINE, [PMID:34044253] [10.1016/j.phymed.2021.153586] |
| 5. Yueyue Wu, Xinmei Huang, Min Yang, Jiong Xu, Zaoping Chen, Zhiyan Yu, Jun Liu. (2018) Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, [PMID:30419520] [10.1016/j.jphotobiol.2018.10.015] |
| 6. Lingli Zheng, Lianhong Yin, Lina Xu, Yan Qi, Hua Li, Youwei Xu, Xu Han, Kexin Liu, Jinyong Peng. (2017) Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. BIOMEDICINE & PHARMACOTHERAPY, [PMID:29091898] [10.1016/j.biopha.2017.10.153] |
| 7. Weixin Zhang, Lianhong Yin, Xufeng Tao, Lina Xu, Lingli Zheng, Xu Han, Youwei Xu, Changyuan Wang, Jinyong Peng. (2016) Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, [PMID:27317992] [10.1016/j.etap.2016.06.002] |
| 8. Cong Li, Li-Tao Yi, Di Geng, Yuan-Yuan Han, Lian-jin Weng. (2015) Hepatoprotective effect of ethanol extract from Berchemia lineate against CCl4-induced acute hepatotoxicity in mice. PHARMACEUTICAL BIOLOGY, [PMID:25431325] [10.3109/13880209.2014.941506] |
| 9. Erqun Song, Juanli Fu, Xiaomin Xia, Chuanyang Su, Yang Song. (2014) Bazhen Decoction Protects against Acetaminophen Induced Acute Liver Injury by Inhibiting Oxidative Stress, Inflammation and Apoptosis in Mice. PLoS One, 9 (9): (e107405). [PMID:25222049] [10.1371/journal.pone.0107405] |
| 10. Jianan Wang, Aqing Jian, Depeng Sun, Mingxun Cui, Chunxiang Piao, Juan Wang, Baide Mu, Tingyu Li, Guanhao Li, Hongmei Li. (2025) Acer tegmeutosum Maxim extract alleviates acute alcohol-induced liver disease and regulates gut microbiota dysbiosis in mice. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, [PMID:39832610] [10.1016/j.abb.2025.110314] |
| 11. Xinyu Huang, Junhong Li, Huan Zhang, Xuemin Duan, Lihua Yao, Ruirui Yue, Jingkun Xu. (2025) Versatile MWCNT-COOH/PEDOT:PSS/Ru composite film used as sensing platform for high-efficiency detection of rutin. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.113515] |
| 12. Weimin Wang, Kaixuan Zhou, Zengshuai Fu, Yucheng Huang, Jianjun Deng, Daidi Fan, Haixia Yang. (2025) Comparison of different ginsenosides with C-3 or C-6 sugar moieties on activities in alcohol-induced liver injury mice. Journal of Ginseng Research, [PMID:41268320] [10.1016/j.jgr.2025.08.003] |
| 13. Hanghang Wang, Chen Chen, Mingzhen Xue, Yu Zhang, Keming Chen, Bingjie Sun, Peipei Wang, Xinyi Tong, Xiong Yu, Han Li, Jia Li, Lihong Hu, Yi Zang, Linguo Zhao, Xiachang Wang, Yinan Zhang. (2025) Identification and mechanism of hepatoprotective saponins and endogenous metabolites in the sweet variant of Gynostemma pentaphyllum. BIOORGANIC CHEMISTRY, [PMID:40966775] [10.1016/j.bioorg.2025.108996] |
| 14. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong. (2023) Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, [PMID:38135203] [10.1016/j.etap.2023.104351] |
| 15. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan. (2023) Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway. FISH PHYSIOLOGY AND BIOCHEMISTRY, [PMID:37542703] [10.1007/s10695-023-01228-y] |
| 16. Qiang-Ming Li, Xiu-Rong Yang, Xue-Qiang Zha, Li-Hua Pan, Dan-Dan Zang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways. CHEMISTRY & BIODIVERSITY, 19 (8): (e202200471). [PMID:35774029] [10.1002/cbdv.202200471] |
| 17. Meirong Huo, Honglan Wang, Ying Zhang, Han Cai, Pan Zhang, Lingchao Li, Jianping Zhou, Tingjie Yin. (2020) Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation. JOURNAL OF CONTROLLED RELEASE, [PMID:32044390] [10.1016/j.jconrel.2020.02.017] |
| 18. Yong Li, Youdong Zhou, Yinqiu Tan, Gang Deng. (2025) Anti-Inflammatory Treatment of Subarachnoid Hemorrhage by Self-Assembled Silymarin Nanoparticles. Small Science, [PMID:40657200] [10.1002/smsc.202400322] |
| 19. Wanpeng Zhou, Ruyao Feng, Miaolian Ma, Zhixuan Hu, Tao Yao, Maofeng Zhang. (2025) Natural flavonoids as highly efficient catalyst for rapid H2 generation from NaBH4 methanolysis in cold climates. Journal of Environmental Chemical Engineering, [PMID:] [10.1016/j.jece.2025.115904] |
| 20. Zhiyi Wang, Zibo Li, Wenlong Yang, Yuyue Li, Ziyang Huang, Zhenzhen Guo, Erping Xu, Ming Bai, Yucheng Li. (2025) Honokiol ameliorates hepatic fibrosis by inducing lysosomal membrane permeabilization and impairing lipophagy in hepatic stellate cells. TOXICOLOGY AND APPLIED PHARMACOLOGY, [PMID:41207513] [10.1016/j.taap.2025.117632] |
| 21. Jiaqi Liu, Wenting Cheng, Hailong Tian, Zhihan Wang, Canhua Huang, Qifu Li. (2026) Brain-Targeting Nanoplatform Repurposing Silymarin for Enhanced GBM Immunotherapy via Synergistic Mitochondrial Suppression. Materials Today Bio, [PMID:41809375] [10.1016/j.mtbio.2026.102951] |
| 22. Yue-qiang Chen, Xiao-xia Dong, Li Liu, Xiu-ping Chen, Chen-guo Feng, Li-xing Zhan, Yue Su, Fang Zhang, Yin-long Guo. (2026) Stable isotope labeling LC–MS for profiling the amine submetabolome in a D-lactate treated cell model. ANALYTICA CHIMICA ACTA, [PMID:] [10.1016/j.aca.2026.345649] |
