Sinefungin - Moligand™, 10 mM in Water , CAS No.58944-73-3

CAS: 58944-73-3 Cat. No.: S1493491 Peso molecular: 381.39 Número EC: 637-385-5 PubChem CID: 65482

GRADE & PURITY Moligand™, 10 mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Sinefungin is a potent inhibitor of virion mRNA (guanine-7-)-methyltransferase, mRNA (nucleoside-2'-)-methyltransferase , and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation.

Specifications

Especificaciones y pureza

Moligand™, 10 mM in Water

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nombres e identificadores

• Isómeros SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O)N
• WGK Alemania: 3
• RTECS: HE3140000
• PubChem CID: 65482
• Peso molecular: 381.39

Referencias

1. Rui-Li Zhu, Ying-Kun Zhi, Lang Yi, Jin-Fang Luo, Jing Li, Sha-Sha Bai, Liang Liu, Pei-Xun Wang, Hua Zhou, Yan Dong.  (2019)  Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via α7nAChR to inhibit inflammation in LPS-stimulated macrophages.  IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,      [PMID:30896303] [10.1080/08923973.2019.1568451]

2. Lang Yi, Yan-jun Lyn, Chong Peng, Rui-li Zhu, Sha-sha Bai, Liang Liu, Pei-xun Wang, Hua Zhou, Yan Dong.  (2018)  Sinomenine inhibits fibroblast-like synoviocyte proliferation by regulating α7nAChR expression via ERK/Egr-1 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:29367088] [10.1016/j.intimp.2018.01.015]

3. Biao Zhou, Xiaolong Lu, Zhi Tang, Dan Liu, Youliang Zhou, Peng Zeng, Hui Xiong.  (2017)  Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:28437887] [10.1016/j.biopha.2017.03.084]