SIRT1-IN-2 - ≥98% , CAS No.2470969-89-0

CAS: 2470969-89-0 Cat. No.: S647959 Peso molecular: 250.72

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Descripción general

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC 50 of 1.6 μM

In Vitro

SIRT1-IN-2 (compound 3h) (0-100 μM, 48 h) inhibits the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, and shows significantly less cytotoxic on 293T cells and HUVEC. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC).Concentration: 0, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 h Result: Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, with IC 50 values of 51, 37, 40, 48, and 48 μM, respectively. And showed significantly less cytotoxic on 293T cells and HUVEC, with IC 50 values of > 100 and 45 μM, respectively.

Form:Solid

IC50& Target:SIRT1 1.6 μM (IC 50 ) SIRT2 39 μM (IC 50 )

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC 50 of 1.6 μM.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Protected from light, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC(C1=C(NC2=CC=C(C=C21)Cl)CC(N)=O)C
• Peso molecular: 250.72

Propiedades químicas y físicas

• Solubilidad: DMSO : 100 mg/mL (398.85 mM; Need ultrasonic)