SKA 121 - Moligand™, ≥98%(HPLC) , Activator of K Ca3.1, CAS No.1820708-73-3, Activator of K Ca3.1

CAS: 1820708-73-3 Cat. No.: S287446 Fórmula: C₁₂H₁₀N₂O Peso molecular: 198.23 PubChem CID: 91827362

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

5-metilnafto[2,1-d]oxazol-2-amina | SKA-121 | 5-metilnafto[2,1-d]oxazol-2-amina, 5-metilnafto[2,1-d]oxazol-2-amina | SKA121 | 5-metilnafto[2,1-d]oxazol-2-amina

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

Descripción del producto：

SKA-121 es un activador selectivo de KCa3.1. SKA-121 exhibe EC50s de 109 nM y 4,4 μM para KCa3.1 y KCa2.3, respectivamente.

Specifications

Sinónimos

5-metilnafto[2,1-d]oxazol-2-amina | SKA-121 | 5-metilnafto[2,1-d]oxazol-2-amina, 5-metilnafto[2,1-d]oxazol-2-amina | SKA121 | 5-metilnafto[2,1-d]oxazol-2-amina

Especificaciones y pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Modulador alostérico positivo de los canales KCa3.1 (potasio activado por Ca2+ de conductancia intermedia) (EC50= 109 nM). Presenta una selectividad de 40 veces para el KCa3.1 sobre el KCa2.3, y de 200 a 400 veces sobre los canales KV y NaV. Potencia la i

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

ACTIVATOR

Mecanismo de acción

Activator of K Ca3.1

Pureza

≥98%(HPLC)

Nombres e identificadores

Sonrisas canónicas

CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N

IUPAC Name

5-methylbenzo[g][1,3]benzoxazol-2-amine

InChIKey

JEGUERWMMMQFJV-UHFFFAOYSA-N

INCHI

1S/C12H10N2O/c1-7-6-10-11(15-12(13)14-10)9-5-3-2-4-8(7)9/h2-6H,1H3,(H2,13,14)

Isómeros SMILES

CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N

PubChem CID

91827362

Términos de entrada MeSH

5-methylnaphtho(2,1-d)oxazol-2-amine;SKA-121

Peso molecular

198.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Naphthalenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Naphthalenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenes
• Alternative Parents: Benzoxazoles Oxazoles Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Primary amines Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Naphthalene - Benzoxazole - Azole - Oxazole - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Oxacycle - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 19.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.91, Max Conc. mM: 50
• Peso molecular: 198.220 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 198.079 Da
• Monoisotopic Mass: 198.079 Da
• Topological Polar Surface Area: 52.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1