SKF 86466 hydrochloride - ≥98%(HPLC) , CAS No.86129-54-6

CAS: 86129-54-6 Cat. No.: S286807 Peso molecular: 232.15 PubChem CID: 10220250

GRADE & PURITY ≥98%(HPLC)

Synonyms

DTXSID70436918 | LP01056 | Skf 86466 | SR-01000076121 | 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride | 1H-3-BENZAZEPINE, 6-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-, HYDROCHLORIDE (1:1) | Tox21_501056 | SKF-86466 hydrochloride, solid, >=9

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

SKF 86466 hydrochloride is a novel selective alpha-2 adrenergic receptor antagonist. Benalfocin reduces blood pressure and heart rate. Benalfocin can be used in the study of cardiovascular effects。

Specifications

Sinónimos

DTXSID70436918 | LP01056 | Skf 86466 | SR-01000076121 | 6-Chloro-2, 3, 4, 5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride | 1H-3-BENZAZEPINE, 6-CHLORO-2, 3, 4, 5-TETRAHYDRO-3-METHYL-, HYDROCHLORIDE (1:1) | Tox21_501056 | SKF-86466 hydrochloride, solid, >=9

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Potent and selectiveα2antagonist at pre- and post-junctionalα2-adrenoceptors (Kivalues are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Pureza

≥98%(HPLC)

Nombres e identificadores

• Sonrisas canónicas: CN1CCC2=C(CC1)C(=CC=C2)Cl.Cl
• IUPAC Name: 6-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepine;hydrochloride
• InChIKey: JKQKVNMNAIFCFS-UHFFFAOYSA-N
• INCHI: 1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H
• Isómeros SMILES: CN1CCC2=C(CC1)C(=CC=C2)Cl.Cl
• PubChem CID: 10220250
• Peso molecular: 232.15

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzazepines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzazepines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzazepines
• Alternative Parents: Azepines Aralkylamines Benzenoids Aryl chlorides Trialkylamines Azacyclic compounds Organopnictogen compounds Organochlorides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzazepine - Azepine - Aralkylamine - Aryl chloride - Aryl halide - Benzenoid - Tertiary amine - Tertiary aliphatic amine - Azacycle - Amine - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ring fused to an azepine ring (unsaturated seven-membered heterocycle with one nitrogen atom replacing a carbon atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERG Tbio Transcriptional regulator ERG (5589 Activities)

Discover Target: ERG

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Objetivos asociados (no humanos)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Cavia porcellus (23802 Activities)

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Canis familiaris (36305 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

Discover Target: Npsr1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:water, Max Conc. mg/mL: 23.21, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 23.21, Max Conc. mM: 100
• Sensibilidad: Light sensitive; Heat sensitive； Moisture sensitive
• Peso molecular: 232.150 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 231.058 Da
• Monoisotopic Mass: 231.058 Da
• Topological Polar Surface Area: 3.200 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 171.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3