Sodium iodoacetate - UltraBio™, ≥99.5%(NT) , CAS No.305-53-3

CAS: 305-53-3 Cat. No.: S755677 Peso molecular: 207.93 Beilstein Registry Number: 4009322 Número EC: 206-165-7
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GRADE & PURITY UltraBio™ ? UltraBio™ — Aladdin's line for molecular-biology applications. Use for nuclease-free, high-consistency reagents across molecular workflows. ≥99.5%(NT)
Synonyms
Iodoacetic acid sodium salt
Storage
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5g
S755677-5g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
105,90US$
25g
S755677-25g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
368,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

UltraBio™, ≥99.5%(NT) UltraBio™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.
Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Specifications

Sinónimos
Iodoacetic acid sodium salt
Especificaciones y pureza
UltraBio™, ≥99.5%(NT)
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C, Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
UltraBio™
Pureza
≥99.5%(NT)
Nombres e identificadores
Sonrisas canónicasC(C(=O)[O-])I.[Na+]
IUPAC Namesodium;2-iodoacetate
InChIKeyAGDSCTQQXMDDCV-UHFFFAOYSA-M
INCHI1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
Isómeros SMILES C(C(=O)[O-])I.[Na+]
WGK Alemania 3
RTECS AI3675000
Número ONU 2811
Peso molecular 207.93
Beilstein 4009322

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClaseCarboxylic acids and derivatives
SubclassAlpha-halocarboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentAlpha-halocarboxylic acids
Alternative Parents Carboxylic acid salts  Organic metal halides  Monocarboxylic acids and derivatives  Carboxylic acids  Organoiodides  Organic sodium salts  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Alkyl iodides  
Molecular FrameworkAliphatic acyclic compounds
Substituents Alpha-halocarboxylic acid - Carboxylic acid salt - Organic metal halide - Carboxylic acid - Organic alkali metal salt - Monocarboxylic acid or derivatives - Alkyl halide - Organic salt - Organooxygen compound - Organoiodide - Organohalogen compound - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Alkyl iodide - Aliphatic acyclic compound
DescripciónThis compound belongs to the class of organic compounds known as alpha-halocarboxylic acids. These are carboxylic acids containing a halogen atom bonded to the alpha carbon atom.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeFechaArticulo
F2622581Certificate of AnalysisJun 06, 2026 S755677
F2622582Certificate of AnalysisJun 06, 2026 S755677
Propiedades químicas y físicas
Solubilidadmethanol: 0.1 M at 20 °C, clear, colorless
SensibilidadLight sensitive;Moisture sensitive
Punto de fusión (°C)208°C
Peso molecular207.930 g/mol
XLogP3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass207.9 Da
Monoisotopic Mass207.9 Da
Topological Polar Surface Area40.100 Ų
Heavy Atom Count6
Formal Charge0
Complexity46.800
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Jiamei LI, An YAN, Mingquan WANG, Di LI.  (2024)  Aptamer and phosphorothioated DNA engineered liposomes as a targeted intracellular protein delivery system.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.cjac.2024.100400]
2. Lu Bocheng, Chen Yongfu, Cai Junjie, Li Ziqi, Guo Lina, Qu Tingli, Tang Li, Zheng Qian.  (2025)  FoxO1/PINK1/Parkin-Dependent Mitophagy Mediates the Chondroprotective Effect of Guzhi Zengsheng Zhitong Decoction in Osteoarthritis.  PHYTOMEDICINE,      [PMID:41038144] [10.1016/j.phymed.2025.157322]
3. Hongxia Fan, Jiansong Zhao, Zhencheng Gao, Yinling Mu, Xiaoman Zhang, Wanbing Pan, Sishu Li, Haibing He, Jingxin Gou, Xing Tang, Tian Yin, Yu Zhang.  (2025)  Injectable self-healing hydrogel loaded PLGA nanoparticles for long-term osteoarthritis therapy.  Biomaterials Advances,      [PMID:41005083] [10.1016/j.bioadv.2025.214506]
4. Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng.  (2023)  Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice.  Advanced Science,      [PMID:37555294] [10.1002/advs.202302586]
5. Yanfei Ban, Yang Wang, Liming Qiao, Chengzhong Zhang, Hongrui Wang, Xuhui He, Dan Jia, Chengjian Zheng.  (2023)  Total lignans from Vitex negundo seeds attenuate osteoarthritis and their main component vitedoin A alleviates osteoclast differentiation by suppressing ERK/NFATc1 signaling.  PHYTOTHERAPY RESEARCH,  37  (4): (1422-1434).  [PMID:36737044] [10.1002/ptr.7750]
6. Xueling Yi, Zhilang Xu, Qisong Liu, Hongmei Zhou, Lun Yuan, Defu Li, Lei Zhao, Changdao Mu, Liming Ge.  (2022)  Matrix metalloproteinase-responsive collagen-oxidized hyaluronic acid injectable hydrogels for osteoarthritic therapy.  Biomaterials Advances,      [PMID:35929283] [10.1016/j.bioadv.2022.212804]
7. Guangzhen Yang, Mengni Fan, Jingwu Zhu, Chen Ling, Lihuang Wu, Xin Zhang, Ming Zhang, Jiayi Li, Qingqiang Yao, Zhongwei Gu, Xiaojun Cai.  (2020)  A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H2O2, and produce large amounts CO for a highly efficient treatment of osteoarthritis.  BIOMATERIALS,      [PMID:32554130] [10.1016/j.biomaterials.2020.120155]
8. Yanhuang Wu, Wenhua Zhang, Qingchun Ge.  (2018)  Piperazine-Based Functional Materials as Draw Solutes for Desalination via Forward Osmosis.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.8b02796]
9. Ximing Wang, Ting Zheng, Luyao Cai, Clara Chen, Junjie Xu, Jinzhong Zhao.  (2025)  Multi-responsive injectable dECM hydrogel for sustained doxycycline delivery in osteoarthritis therapy.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2025.114785]
10. Min Song, Weichang Han, Jingyi Li, Gaoyi Wu, Haibo Yu, Qing Yuan, Jiani Yu.  (2025)  Monosodium Iodoacetate Induces Knee Osteoarthritis in Rats in a Dose- and Time-Dependent Manner.  Journal of Pain Research,      [PMID:41127857] [10.2147/JPR.S527135]
11. Wenjin Dai, Mengjun Zeng, Lu Zhang, Guangwei Shi, Hong Wang, Chengyi Xu, Riguang Zhao, Cong Zhang, Jiu Wang, Liqun Jiang.  (2025)  A Kneading-Responsive Hyaluronic Acid-based Hydrogel for On-Demand Local Anesthesia in Osteoarthritis.  Acta Biomaterialia,      [PMID:41344594] [10.1016/j.actbio.2025.12.001]
12. Yu Xi, Li Yajie, Chen Xiaping, Cheng Junhua, Yu Xinhua, Xu Xueqin, Xiao Qin, Zhu Xiaohu, Ke Changbin.  (2026)  Cldn11 deficiency aggravates osteoarthritis by inhibiting Notch signalling in a Tspan5-dependent manner.  Journal of Orthopaedic Surgery and Research,  21  (1): (2).  [PMID:41485015] [10.1186/s13018-025-06529-x]
13. Lixian Huang, Jiaqi Lu, Yidong Bin, Min He, Caiying Li, Shulin Zhao, Shulong Wang, Liangliang Zhang.  (2026)  Hydroxyl Radical–Activatable NIR-II Ratiometric Fluorescence Probe for Visualization In Vivo Tracking of Oxidative Stress and Therapeutic Response in Arthritis.  ANALYTICAL CHEMISTRY,      [PMID:] [10.1021/acs.analchem.6c00450]
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