Sodium salicylate - AR, ≥99.5%(NT) , CAS No.54-21-7

CAS: 54-21-7 Cat. No.: S104176 Peso molecular: 160.1 Beilstein Registry Number: 3732792 Número EC: 200-198-0 PubChem CID: 16760658
Disponible para pedir
GRADE & PURITY AR ? Analytical Reagent grade — high-purity chemicals meeting strict assay limits for lab analysis. Use when accuracy matters and trace impurities could skew results. ≥99.5%(NT)
Synonyms
SALICYLATE SODIUM [WHO-DD] | Sodium salicylate, SAJ first grade, >=99.5% | DTXCID701708 | Sodium salicylate, puriss. p.a., >=99.5% (NT) | HMS1920P16 | Salicylic acid sodium salt;2-Hydroxybenzoic acid sodium salt | Salsonin | CCG-39474 | Nadisal | NCGC0009
Storage
Protected from light,Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
250g
S104176-250g
≥10
11,90US$
500g
S104176-500g
3
21,90US$
12×500g
S104176-12×500g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
228,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

AR, ≥99.5%(NT) AR for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 122 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro.Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel?Biskis?Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.
An NF kappa B inhibitor and reducer of oxidative stress.

Specifications

Sinónimos
SALICYLATE SODIUM [WHO-DD] | Sodium salicylate, SAJ first grade, >=99.5% | DTXCID701708 | Sodium salicylate, puriss. p.a., >=99.5% (NT) | HMS1920P16 | Salicylic acid sodium salt;2-Hydroxybenzoic acid sodium salt | Salsonin | CCG-39474 | Nadisal | NCGC0009
Especificaciones y pureza
AR, ≥99.5%(NT)
Mecanismos bioquímicos y fisiológicos
Sodium salicylate is a metabolite of acetylsalicylic acid, and functions by inhibiting NF κ B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin , sodium salicyl
Condiciones de almacenamiento de almacenamiento
Protected from light, Room temperature
Enviado en
Normal
Grado
AR
Pureza
≥99.5%(NT)
Nombres e identificadores
Pubchem Sid488199435
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488199435
Sonrisas canónicasC1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
IUPAC Namesodium;2-hydroxybenzoate
InChIKeyABBQHOQBGMUPJH-UHFFFAOYSA-M
INCHI1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
Isómeros SMILES C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
WGK Alemania 1
RTECS VO5075000
PubChem CID 16760658
Peso molecular 160.1
Beilstein 3732792

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClaseBenzene and substituted derivatives
SubclassBenzoic acids and derivatives
Intermediate Tree Nodes Hydroxybenzoic acid derivatives - Salicylic acid and derivatives
Direct ParentSalicylic acids
Alternative Parents Benzoic acids  Benzoyl derivatives  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Vinylogous acids  Carboxylic acid salts  Monocarboxylic acids and derivatives  Carboxylic acids  Organooxygen compounds  Organic sodium salts  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Salicylic acid - Benzoic acid - Benzoyl - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Vinylogous acid - Carboxylic acid salt - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic salt - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Organic oxygen compound - Organic sodium salt - Aromatic homomonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids.
External Descriptors organic molecular entity
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

46 results found

Lot NumberCertificate TypeFechaArticulo
F2603555Certificate of AnalysisMay 22, 2026 S104176
F2603554Certificate of AnalysisMay 22, 2026 S104176
F2603553Certificate of AnalysisMay 22, 2026 S104176
F2230214Certificate of AnalysisApr 03, 2026 S104176
F2609189Certificate of AnalysisJan 21, 2026 S104176
B2604363Certificate of AnalysisJan 21, 2026 S104176
B2604360Certificate of AnalysisJan 21, 2026 S104176
B2604361Certificate of AnalysisJan 21, 2026 S104176
L2522047Certificate of AnalysisAug 06, 2025 S104176
H2519497Certificate of AnalysisAug 06, 2025 S104176
H2519485Certificate of AnalysisAug 06, 2025 S104176
H2519386Certificate of AnalysisAug 06, 2025 S104176
D2517559Certificate of AnalysisApr 07, 2025 S104176
D2517558Certificate of AnalysisApr 07, 2025 S104176
D2517556Certificate of AnalysisApr 07, 2025 S104176
D2517469Certificate of AnalysisApr 07, 2025 S104176
B2518451Certificate of AnalysisFeb 10, 2025 S104176
B2518450Certificate of AnalysisFeb 10, 2025 S104176
B2518452Certificate of AnalysisFeb 10, 2025 S104176
I2424728Certificate of AnalysisJul 10, 2024 S104176
H2409363Certificate of AnalysisJul 10, 2024 S104176
H2409362Certificate of AnalysisJul 10, 2024 S104176
A2419568Certificate of AnalysisJan 30, 2024 S104176
A2419581Certificate of AnalysisJan 30, 2024 S104176
J2310605Certificate of AnalysisOct 19, 2023 S104176
J2310602Certificate of AnalysisOct 16, 2023 S104176
J2310603Certificate of AnalysisOct 16, 2023 S104176
J2310604Certificate of AnalysisOct 16, 2023 S104176
B23171126Certificate of AnalysisJan 31, 2023 S104176
B23171103Certificate of AnalysisJan 31, 2023 S104176
B23171102Certificate of AnalysisJan 31, 2023 S104176
B23171127Certificate of AnalysisJan 31, 2023 S104176
E2422070Certificate of AnalysisJan 31, 2023 S104176
B23171128Certificate of AnalysisJan 31, 2023 S104176
K2215766Certificate of AnalysisNov 02, 2022 S104176
K2215815Certificate of AnalysisNov 02, 2022 S104176
K2215848Certificate of AnalysisNov 02, 2022 S104176
K2215849Certificate of AnalysisNov 02, 2022 S104176
K2225088Certificate of AnalysisNov 02, 2022 S104176
F2230210Certificate of AnalysisJun 09, 2022 S104176
F2230215Certificate of AnalysisJun 09, 2022 S104176
F2230209Certificate of AnalysisJun 09, 2022 S104176
A2219040Certificate of AnalysisNov 27, 2021 S104176
A2219069Certificate of AnalysisNov 27, 2021 S104176
A2219057Certificate of AnalysisNov 27, 2021 S104176
A2219052Certificate of AnalysisNov 27, 2021 S104176

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Propiedades químicas y físicas
SolubilidadSoluble in water, 1,4-dioxane, ethanol and glycerol.
SensibilidadLight sensitive.
Punto de inflamación (°C)98.3 °C
Punto de ebullición (°C)213 °C
Punto de fusión (°C)>300℃
Peso molecular160.100 g/mol
XLogP3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass160.014 Da
Monoisotopic Mass160.014 Da
Topological Polar Surface Area60.400 Ų
Heavy Atom Count11
Formal Charge0
Complexity138.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Yameng Zhu, Mengxuan Wu, Xinxin Miao, Boyao Wang, Jun He, Xilong Qiu.  (2023)  Delivery of paclitaxel by carboxymethyl chitosan-functionalized dendritic fibrous nano-silica: Fabrication, characterization, controlled release performance and pharmacokinetics.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38029896] [10.1016/j.ijbiomac.2023.128431]
2. Zhao Sheng-Nan, Tang Run-Hua, Deng Shu-Jun, Chen Gui-E, Ye Jing, Xu Zhen-Liang.  (2023)  Dual gatekeepers-modified dendritic mesoporous silica nanoparticles for controlled drug release.  JOURNAL OF MATERIALS SCIENCE,  58  (46): (17610-17622).  [PMID:] [10.1007/s10853-023-09128-5]
3. Xinchu Wang, Jun Wu, Danzhou Huang, Jiaheng Yan, Changwen Li, Zhiqiang Ren, Jinhua Li, Xianbao Wang, Jianying Wang.  (2023)  Constructing highly efficient and ultra-stable (against Temperature, Humidity and Sunlight) luminescent solar concentrators by using dendritic CsPbBr3@SiO2 particles.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.148139]
4. Hongjing Wang, Lin Cui, Songliang Liu, Hongjie Yu, Kai Deng, You Xu, Xiaonian Li, Ziqiang Wang, Liang Wang.  (2023)  Ultrafine AuCu nanowires for electrocatalytic nitrogen fixation.  Inorganic Chemistry Frontiers,  11  (3): (892-898).  [PMID:] [10.1039/D3QI01771K]
5. Wei Wang, Yaling Zheng, Haibo Li, Chengjiang Wei, Luodan Yu, Yihui Gu, Qingfeng Li, Yu Chen, Zhichao Wang.  (2023)  Multifunctional chemoreactive nanosonosensitizers exert antitumoral, antibacterial and wound healing effects on malignant peripheral nerve sheath tumors.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.147162]
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7. Xinqiang Liang, Mekhrdod S. Kurboniyon, Yuanhan Zou, Kezong Luo, Shuhong Fang, Pengle Xia, Shufang Ning, Litu Zhang, Chen Wang.  (2023)  GSH-Triggered/Photothermal-Enhanced H2S Signaling Molecule Release for Gas Therapy.  Pharmaceutics,  15  (10): (2443).  [PMID:37896203] [10.3390/pharmaceutics15102443]
8. Hua Li, Mudong Tu, Yahan Fang, Tianzhi Hao, Baodui Wang.  (2023)  Cu/2D-CuOx Nanocomposites with Abundant Oxygen Vacancy Defects for Enhancing Ammonia Selectivity of Electrocatalytic Nitrate Reduction.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.3c03504]
9. Xuehao Zhang, Han Jia, Guopeng Wu, Mingming Xu, Chuanqi Li, Ziwei Wei, Wenxin Cao, Xiyang Wang, Kaihe Lv, Dexin Liu, Pan Huang.  (2023)  Performance evaluation and formation mechanism of Janus-SiO2 nanoparticles assisted viscoelastic surfactant fracturing fluids.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2023.123203]
10. Jia Tan, Binbin Ding, Hao Chen, Qi Meng, Jing Li, Chunzheng Yang, Wenying Zhang, Xinyang Li, Di Han, Pan Zheng, Ping'an Ma, Jun Lin.  (2023)  Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy.  Small,      [PMID:37702141] [10.1002/smll.202305567]
11. Yan He, Shiyang Wu, Yibo Yuan, Yueci Sun, Qiangjuan Ai, Ruiqi Zhou, Guozhi Chai, Dawei Chen, Haiyang Hu.  (2023)  Remodeling tumor immunosuppression with molecularly imprinted nanoparticles to enhance immunogenic cell death for cancer immunotherapy.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37579978] [10.1016/j.jconrel.2023.08.026]
12. Han Jia, Xuehao Zhang, Qiuxia Wang, Mingming Xu, Lingyu Zhang, Jiajun Dai, Qiang Wang, Fangning Fan, Dexin Liu, Hongyan Wu.  (2023)  Performance Evaluation and Formation Mechanism of Viscoelastic Surfactant Fracturing Fluids with Moderate Interfacial Activity Enhanced by Janus-SiO2 Nanoparticles.  LANGMUIR,      [PMID:37535862] [10.1021/acs.langmuir.3c01431]
13. Tianxiao Yang, Pingping Zhou, Ziwei Zhang, Xinyu Hao, Shaowei Liu, Haoyu Chen, Yuhua Wang, Yangang Wang.  (2023)  Therapeutic Effects of Huazhuojiedu Decoction on Precancerous Lesions of Gastric Cancer by Regulating Mitophagy.  Jove-Journal of Visualized Experiments,      [PMID:37458458] [10.3791/65271]
14. Kangfeng Dong, Shaolong Wu, Baisong Chang, Taolei Sun.  (2023)  Zero-valent iron supported by dendritic mesoporous silica nanoparticles to purify dye wastewater.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2023.110434]
15. Hongxia Yang, Xuefang Zhu, Kai Hua, Fengzhong Yuan, Jing Zhang, Yucheng Jiang.  (2023)  Spatial distribution and proximity effect-dependent multi-enzyme cascades catalysis operating in dendritic mesoporous silica nanoparticles.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2023.113290]
16. Jingbao Wang, Jingmao Zhao, Mohammad Tabish, Fan Shi, Baomin Fan, Lijun Peng, Qi Cheng.  (2023)  Intelligent anticorrosion coating based on mesostructured BTA@mCeO2/g-C3N4 nanocomposites for inhibiting the filiform corrosion of Zn-Mg-Al coated steel.  CORROSION SCIENCE,      [PMID:] [10.1016/j.corsci.2023.111331]
17. Zhihao Zhang, Tan Wang, Jun Song Chen, Kai Dong, Shengjun Sun, Yongsong Luo, Haoran Guo, Xuping Sun, Tingshuai Li.  (2023)  Cr3C2 nanoparticles decorated carbon nanofibers for efficient nitrate reduction to ammonia at ambient conditions.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:37321088] [10.1016/j.jcis.2023.05.186]
18. Haiying Wei, Licheng Li, Tingwei Zhang, Farzad Seidi, Huining Xiao.  (2023)  Platinum-loaded dendritic mesoporous silica as novel ethylene scavenger to extend shelf life of banana (Musa nana).  FOOD CHEMISTRY,      [PMID:37257279] [10.1016/j.foodchem.2023.136415]
19. Geng Yang, Ting Song, Hanxi Zhang, Mengyue Li, Xiaodan Wei, Wanyi Zhou, Chunhui Wu, Yiyao Liu, Hong Yang.  (2023)  Stimulus-Detonated Biomimetic “Nanobomb” with Controlled Release of HSP90 Inhibitor to Disrupt Mitochondrial Function for Synergistic Gas and Photothermal Therapy.  Advanced Healthcare Materials,      [PMID:37200205] [10.1002/adhm.202300945]
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25. Shanshan Niu, Lei-Lei Qian, Pan Du, Nan Si, Dawei Jiang, Yan Feng, Bin Huang, Xiaomin Gu, Qiang Zhao, Jiao Ji, Hua Zhu.  (2022)  Enhanced Ammonia Synthesis by Mo2+-Rich Graphene-Based Nanocomposite.  Nano Life,      [PMID:] [10.1142/S1793984422500131]
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40. Mingwei Gao, Peng Liu, Qiang Xue, Mingwei Zhao, Xu Guo, Qing You, Caili Dai.  (2022)  Non-ionic polar small molecules induced transition from elastic hydrogel via viscoelastic wormlike micelles to spherical micelles in zwitterionic surfactant systems.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.119343]
41. Yuan Zhang, Weina Meng, Xiao Li, Dong Wang, Shaomin Shuang, Chuan Dong.  (2022)  Dendritic Mesoporous Silica Nanoparticle-Tuned High-Affinity MnO2 Nanozyme for Multisignal GSH Sensing and Target Cancer Cell Detection.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.2c00259]
42. Zhiying Guo, Fangxu Dai, Huixiang Yin, Mingming Zhang, Jun Xing, Lei Wang.  (2022)  The dual role of Au nanoparticles in the surface plasmon resonance enhanced photocatalyst Au/g-C3N4.  Colloid and Interface Science Communications,      [PMID:] [10.1016/j.colcom.2022.100615]
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