SP600125 - Moligand™, ≥98% , Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9, CAS No.129-56-6, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

CAS: 129-56-6 Cat. No.: S125267 Peso molecular: 220.233 Número EC: 204-955-6 PubChem CID: 8515

GRADE & PURITY Moligand™, ≥98%

Synonyms

HMS1362F07 | KBioGR_000406 | Anthra[1-9-cd]pyrazol-6(2H)-one | SDCCGSBI-0050458.P003 | WLN: T C66651A P IV OMNJ | Pyrazolanthrone | Pyrazoleanthrone | HMS3295M01 | 2,6-dihydrodibenzo[cd,g]indazol-6-one | JMC517015 Compound 2 | Bio1_001313 | NCGC00015958-0

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3

Specifications

Sinónimos

HMS1362F07 | KBioGR_000406 | Anthra[1-9-cd]pyrazol-6(2H)-one | SDCCGSBI-0050458.P003 | WLN: T C66651A P IV OMNJ | Pyrazolanthrone | Pyrazoleanthrone | HMS3295M01 | 2, 6-dihydrodibenzo[cd, g]indazol-6-one | JMC517015 Compound 2 | Bio1_001313 | NCGC00015958-0

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

SP600125 is selective inhibitor of c-Jun N-terminal kinase (JNK). SP600125 competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 ＞ 10 μM). Active in vivo. Shown

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504751698
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751698
• Sonrisas canónicas: C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
• IUPAC Name: 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
• InChIKey: ACPOUJIDANTYHO-UHFFFAOYSA-N
• INCHI: 1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
• Isómeros SMILES: C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
• PubChem CID: 8515
• Peso molecular: 220.233

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Anthracenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Anthracenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Anthracenes
• Alternative Parents: Indazoles Aryl ketones Pyrazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Anthracene - Benzopyrazole - Indazole - Aryl ketone - Heteroaromatic compound - Pyrazole - Azole - Ketone - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as anthracenes. These are organic compounds containing a system of three linearly fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

MAPK10 Tchem Mitogen-activated protein kinase 10 (2 Activities)

Discover Target: MAPK10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK8 Tchem Mitogen-activated protein kinase 8 (1 Activities)

Discover Target: MAPK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK9 Tchem Mitogen-activated protein kinase 9 (1 Activities)

Discover Target: MAPK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
• Sensibilidad: Heat Sensitive
• Punto de fusión (°C): 283°C
• Peso molecular: 220.230 g/mol
• XLogP3: 2.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 220.064 Da
• Monoisotopic Mass: 220.064 Da
• Topological Polar Surface Area: 45.800 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 343.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Lin Zhao, Liyuan Wang, Han Wang, Tao Xi, Sijia Liu, Yang Li, Jianping Ruan, Yongqing Huang.  (2023)  Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.  ENVIRONMENTAL TOXICOLOGY,  38  (7): (1756-1767).  [PMID:37070943] [10.1002/tox.23805]

2. Niu Ting, Wei Zhiying, Fu Jiao, Chen Shu, Wang Ru, Wang Yuya, Zheng Ruihe.  (2023)  Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway.  Frontiers in Pharmacology,      [PMID:36686679] [10.3389/fphar.2022.1080412]

3. Xing Ying, Liu Yang, Qi Zhong, Liu Zhengrong, Wang Xin, Zhang Hongyi.  (2021)  LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  26  (1): (1-16).  [PMID:34837962] [10.1186/s11658-021-00295-4]

4. Bai Yu, Du Qiang, Zhang Le, Li Ling, Wang Nana, Wu Bo, Li Ping, Li Ling.  (2021)  Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells.  Frontiers in Endocrinology,      [PMID:34163433] [10.3389/fendo.2021.635321]

5. Zhaohui Shi, Min Xu, Xiaodong Chen, Jian Wang, Tianfeng Zhao, Dingjun Zha.  (2020)  The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells.  EXPERIMENTAL AND MOLECULAR PATHOLOGY,      [PMID:33285209] [10.1016/j.yexmp.2020.104591]

6. Tian Xusheng, Zhang Yukun, Li Han, Li Yunfeng, Wang Ning, Zhang Wei, Ma Boyan.  (2020)  Palmatine ameliorates high fat diet induced impaired glucose tolerance.  BIOLOGICAL RESEARCH,  53  (1): (1-12).  [PMID:32928312] [10.1186/s40659-020-00308-0]

7. Kang An, Yuehan Zhang, Yingjiao Liu, Shengxi Yan, Zhaowei Hou, Meng Cao, Guangkuo Liu, Congcong Dong, Juncha Gao, Gaifang Liu.  (2020)  Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.  ONCOLOGY REPORTS,  44  (3): (1116-1126).  [PMID:32705225] [10.3892/or.2020.7675]

8. Yichao Du, Junjie Bai, Tingting Ma, Ziming Wu, Pengru Wang, Xiaolin Zhong, Wenguang Fu, Shuixiang He.  (2025)  Sinomenine Ameliorates Liver Fibrosis by Blocking TGF-β/SMAD and c-JUN Signaling.  PHYTOTHERAPY RESEARCH,      [PMID:40452107] [10.1002/ptr.8502]