Span 20 - non-ionic , CAS No.1338-39-2

CAS: 1338-39-2 Cat. No.: S102859 Beilstein Registry Number: 8355657 Número EC: 215-663-3

GRADE & PURITY non-ionic

Synonyms

SR-01000883734 | 1219114-53-0 | Span20 | 2-((2R,3R,4S)-3,4-Dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl dodecanoate | Sorbitan monolaurate | MFCD00005365 | J-006440 | Span(R) 20 | AKOS040744631 | LWZFANDGMFTDAV-WYDSMHRWSA-N | Q12642435 | Span 20 | SR-010

Storage

Room temperature

Shipped In

Normal

Descripción general

Span™ 20 is a sorbitan monolaurate for use as a wetter, emulsifier, emulsifier O/W, and emulsifier W/O. It is part of a broad range of ester materials including sorbitan esters, mono and diglycerides, and polyoxyethylene sorbitol esters. These nonionic surfactants can function as emulsifiers, detergents, spreading or dispersing agents. It finds wide use in the personal care industry. Manufacturer：Croda
Span 20 has been used in a study to assess enhanced solubility and oral bioavailability of itraconazole. It has also been used in a study to investigate the oxidation of unsaturated lipids in oil-in-water emulsions.

application：

Span 20 has been used in a study to assess enhanced solubility and oral bioavailability of itraconazole. It has also been used in a study to investigate the oxidation of unsaturated lipids in oil-in-water emulsions.

Specifications

Sinónimos

SR-01000883734 | 1219114-53-0 | Span20 | 2-((2R, 3R, 4S)-3, 4-Dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl dodecanoate | Sorbitan monolaurate | MFCD00005365 | J-006440 | Span(R) 20 | AKOS040744631 | LWZFANDGMFTDAV-WYDSMHRWSA-N | Q12642435 | Span 20 | SR-010

Especificaciones y pureza

non-ionic

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Nombres e identificadores

• Pubchem Sid: 488199314
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488199314
• Sonrisas canónicas: CCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O
• IUPAC Name: [2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate
• InChIKey: LWZFANDGMFTDAV-WYDSMHRWSA-N
• INCHI: 1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15?,17+,18+/m0/s1
• Isómeros SMILES: CCCCCCCCCCCC(=O)OCC([C@@H]1[C@@H]([C@H](CO1)O)O)O
• WGK Alemania: 1
• RTECS: WG2920000
• Beilstein: 8355657
• Reaxy-Rn: 11323087
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11323087&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Fatty acid esters

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Fatty acid esters
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acid esters
• Alternative Parents: Oxolanes Secondary alcohols Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Fatty acid ester - Oxolane - Carboxylic acid ester - Secondary alcohol - Carboxylic acid derivative - Dialkyl ether - Ether - Monocarboxylic acid or derivatives - Oxacycle - Organoheterocyclic compound - Carbonyl group - Organic oxide - Alcohol - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in 2-ethoxyethanol, ethanol and methanol. Not miscible or difficult to mix in water.
• Sensibilidad: Moisture sensitive.
• Punto de inflamación (°F): 113 °C
• Punto de inflamación (°C): 113°C
• Peso molecular: 346.500 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 14
• Exact Mass: 346.236 Da
• Monoisotopic Mass: 346.236 Da
• Topological Polar Surface Area: 96.200 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 335.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Yajie Ding, Nianxiang Qiu, Jianqiang Wang, Zhe Yang, Fu Liu, Chuyang Y. Tang.  (2023)  Oil-water receiving membrane with sub-10 nm surfactant layer for long-lasting oil-water separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.121820]

2. Zihao Meng, Jian Wu, Qingyun Li, Youyan Liu, Aixing Tang.  (2023)  Effective immobilization of candida cylindracea lipase on surfactant-modified bentonite.  MOLECULAR CRYSTALS AND LIQUID CRYSTALS,      [PMID:] [10.1080/15421406.2022.2096553]

3. Fan Xiao, Kai Li, Wei Wang, Yuntong Ge, Zhipeng Yu, Zeheng Peng, Yingming Liu, Jing Gong.  (2023)  Effect of Oil-Soluble/Water-Soluble Surfactants on the Stability of Water-in-Oil Systems, an Atomic Force Microscopy Study.  LANGMUIR,      [PMID:36908066] [10.1021/acs.langmuir.2c02992]

4. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao.  (2023)  Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.141780]

5. Yuanxing Ning, Minghui Yao, Yuxing Li, Guangchun Song, Zhiming Liu, Qingping Li, Haiyuan Yao, Wuchang Wang.  (2022)  Integrated investigation on the nucleation and growing process of hydrate in W/O emulsion containing asphaltene.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.140389]

6. Zhen Yang, Yuanpeng Yao, Huiying Wu.  (2022)  Effects of surfactants on subcooled pool boiling characteristics: An experimental study.  INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER,      [PMID:] [10.1016/j.ijheatmasstransfer.2022.123419]

7. Minhua Li, Xue Dong, Tieling Xing, Guoqiang Chen.  (2022)  Anti-Wrinkle and Dyeing Properties of Silk Fabric Finished with 2,4,6-Trichloropyrimidine.  Polymers,  14  (16): (3332).  [PMID:36015590] [10.3390/polym14163332]

8. Linghui Zou, Wenya Ding, Qiuyan Huang, Xu Yang, Jilang Li, Tianyan Huang, Zeyu Li, Si Lin, Jianfang Feng.  (2022)  Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, in Vitro and in Vivo Evaluation.  BIOLOGICAL & PHARMACEUTICAL BULLETIN,  45  (8): (1106-1115).  [PMID:35598976] [10.1248/bpb.b22-00154]

9. Hanqi Xu, Jinbo Wu, Yaying Hong, Weijia Wen.  (2021)  The surfactant effect on electrorheological performance and colloidal stability.  Soft Matter,  17  (30): (7158-7167).  [PMID:34259280] [10.1039/D1SM00685A]

10. Huihui Huang, Yuqing Sun, Lele Cui, Yingxiang Ni, Shilong Li, Weihong Xing, Wenheng Jing.  (2020)  Generation of Monodisperse Submicron Water-in-Diesel Emulsions via a Hydrophobic MXene-Modified Ceramic Membrane.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.0c03837]

11. Xue Dong, Tieling Xing, Guoqiang Chen.  (2020)  Improving the Anti-Pilling Performance of Cellulose Fiber Blended Knitted Fabrics with 2,4,6-Trichloropyrimidine Treatment.  Coatings,  10  (10): (969).  [PMID:] [10.3390/coatings10100969]

12. Jiayuan Wang, Wenqi Cao, Lingyu Zhu, Jianli Wang, Richard Lakerveld.  (2020)  Emulsion-assisted cooling crystallization of ibuprofen.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2020.115861]

13. Shikang Meng, Lin Sun, Lun Wang, Zibei Lin, Zeyu Liu, Long Xi, Zhenping Wang, Ying Zheng.  (2019)  Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:31306831] [10.1016/j.colsurfb.2019.110352]

14. Wei Li, Gang Wu, Jinhui Tan, Xufeng Yu, Gang Sun, Bo You.  (2019)  Transparent Surfactant/Epoxy Composite Coatings with Self-Healing and Superhydrophilic Properties.  MACROMOLECULAR MATERIALS AND ENGINEERING,  304  (7): (1800765).  [PMID:] [10.1002/mame.201800765]

15. Xiyao Zhang, Jianlei Niu, Jian-Yong Wu.  (2019)  Development and characterization of novel and stable silicon nanoparticles-embedded PCM-in-water emulsions for thermal energy storage.  APPLIED ENERGY,      [PMID:] [10.1016/j.apenergy.2019.01.159]

16. Xin Sun, Chunying Zhu, Taotao Fu, Youguang Ma, Huai Z. Li.  (2018)  Dynamics of droplet breakup and formation of satellite droplets in a microfluidic T-junction.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2018.05.027]

17. Dong Dong, Enxi Quan, Xue Yuan, Qian Xie, Zhijie Li, Baojian Wu.  (2016)  Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism.  MOLECULAR PHARMACEUTICS,      [PMID:27983856] [10.1021/acs.molpharmaceut.6b00851]

18. Zonghao Wang, Yanyan Nie, Peiyuan Shang, Zheng Chen, Bin Cheng.  (2024)  Chemical stability of sorbitan monolaurate under highly oxidative electrochemical environments.  CHEMICAL PAPERS,      [PMID:] [10.1007/s11696-024-03388-4]

19. Sisi Yuan, Xiujun Wang, Yongjun Wang, Ming Duan, Yan Xiong, Shenwen Fang.  (2024)  Comparative study on the performance and properties of polyether and polyacrylate crude oil demulsifier.  SEPARATION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01496395.2024.2328671]

20. Xiao-Fang Lv, Xing-Ya Ni, Yan-Yun Xiao, Yang Liu, Ming-Guo Peng, Qian-Li Ma, Chuan-Shuo Wang, Shi-dong Zhou, Shang-Fei Song.  (2024)  Experimental study on gas separation from the oil–water-emulsion mixture via hydrate method.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2024.120198]

21. Yuqing Sun, Chenye Dai, Jian Lu, Yapeng Zhu, Yingxuan Deng, Xianyin Cai, Dong Zou, Wenheng Jing.  (2024)  In-situ thermally induced formation of an ultra-glossy hydrophilic surface for oil fouling prevention in TiO2@MXene membranes.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.130599]

22. Wenyan Liu, Jingxia Cao, Qixin Zhang, Weiqin Wang, Yuanping Ye, Senwang Zhang, Leiyan Wu.  (2024)  Interfacial Properties and Structure of Emulsions and Foams Co-Stabilized by Span Emulsifiers of Varying Carbon Chain Lengths and Egg Yolk Granules.  Foods,  14  (1): (35).  [PMID:39796325] [10.3390/foods14010035]

23. Xin Lv, Shi Shen, Huiyong Liang, Yanzhen Liu, Haiyuan Yao, Rui Qin, Haihong Chen, Yang Ge, Peng Xiao.  (2024)  Study on the mixed deposition rate and phase transition thermodynamic parameters of crude oil wax crystals and hydrates.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2024.121022]

24. Ruoning Zhang, Yanhui Zhang, Tingnan Song, Song Miao, Yanxiang Gao, Like Mao.  (2025)  Shear-responsive oleogels with improved lubrication in oral conditions.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.167053]

25. Zhiyi Zang, Yongkang Wang, Wei Liu, Congcong Chao, Guanghui Cui, Shaojun Wu, Zhanpeng Wu.  (2025)  Amphiphilic Polyphosphazene-Stabilized High Internal Phase Emulsions toward Porous Polymers with Designed Hydrophilicity and Hydrophobicity for Selective Adsorption of Water and Oil.  LANGMUIR,      [PMID:40990335] [10.1021/acs.langmuir.5c02759]

26. Lei Ren, Yangnan Hu, Xiaoqiong Ding, Menghui Liao, Tian Shen, Sixing Cao, Hui Zhang, Hong Cheng, Yanru Qi, Pan Feng, Xinyi Pang, Ling Lu, Huan Wang, Wenwen Liu, Renjie Chai, Lin Cheng.  (2025)  Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation.  Advanced Science,  12  (21): (2412158).  [PMID:40354610] [10.1002/advs.202412158]

27. Linghua Zhang, Shu Yang, Ahmed S.M. Saleh, Rui Wang, Zhigang Xiao.  (2025)  Influence of Emulsifier Type on Sunflower Oil Oleogels Structured with Ethylcellulose.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2025.118841]