≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base. However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts. These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.
Application：
Sphingomyelin (Brain, Porcine) is suitable:
· as a standard for high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS)
· as a supplement for cell vacuolation of Hela cells
· for preparation of liposomes
| Pubchem Sid | 504764233 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764233 |
| Isómeros SMILES | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)[C@@H](/C=C/CCCCCCCCCCCCC)O |
| PubChem CID | 6453725 |
| Peso molecular | 760.223 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 K2212371 | Certificate of Analysis | May 11, 2026 | S130560 |
| K2212372 | Certificate of Analysis | May 11, 2026 | S130560 |
| J2408669 | Certificate of Analysis | Sep 18, 2024 | S130560 |
| J2408676 | Certificate of Analysis | Sep 18, 2024 | S130560 |
| K2505045 | Certificate of Analysis | Sep 18, 2024 | S130560 |
| A2002049 | Certificate of Analysis | Aug 07, 2023 | S130560 |
| Peso molecular | 731.100 g/mol |
|---|---|
| XLogP3 | 13.400 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 38 |
| Exact Mass | 730.599 Da |
| Monoisotopic Mass | 730.599 Da |
| Topological Polar Surface Area | 108.000 Ų |
| Heavy Atom Count | 50 |
| Formal Charge | 0 |
| Complexity | 826.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
