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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items SR 8278 - Moligand™, ≥98% , Antagonist of Rev-Erb-α, CAS No.1254944-66-5, Antagonist of Rev-Erb-α
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate | 1254944-66-5 | Q27088866 | SR8278, >=98%, semisolid | AKOS024458171 | GTPL2904 | SCHEMBL20488638 | 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoqui
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Sinónimos
ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3, 4-dihydro-1H-isoquinoline-3-carboxylate | 1254944-66-5 | Q27088866 | SR8278, >=98%, semisolid | AKOS024458171 | GTPL2904 | SCHEMBL20488638 | 1, 2, 3, 4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoqui
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
Rev-Erbαantagonist; inhibits Rev-Erbαtranscriptional repression (EC50= 0.47μM). Blocks activity of Rev-ErbαagonistGSK 4112 in HEK293 cells. Increases expression of glucose-regulating genes, G6PaseandPEPCKin HepG2 cells.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Mecanismo de acción
Antagonist of Rev-Erb-α
Nombres e identificadores Pubchem Sid 504771188 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771188 Sonrisas canónicas CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC IUPAC Name ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate InChIKey UIEBLUZPSFAFOC-UHFFFAOYSA-N INCHI 1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3 Isómeros SMILES CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC WGK Alemania 3 PubChem CID 53393127 Peso molecular 361.48
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Clase Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives Direct Parent Alpha amino acid esters Alternative Parents Tetrahydroisoquinolines Thiophene carboxamides 2-heteroaryl carboxamides 2,5-disubstituted thiophenes Alkylarylthioethers Benzenoids Tertiary carboxylic acid amides Heteroaromatic compounds Carboxylic acid esters Sulfenyl compounds Azacyclic compounds Monocarboxylic acids and derivatives Organonitrogen compounds Organic oxides Carbonyl compounds Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Alpha-amino acid ester - Tetrahydroisoquinoline - 2-heteroaryl carboxamide - Aryl thioether - Thiophene carboxamide - Thiophene carboxylic acid or derivatives - 2,5-disubstituted thiophene - Alkylarylthioether - Benzenoid - Tertiary carboxylic acid amide - Thiophene - Heteroaromatic compound - Carboxylic acid ester - Carboxamide group - Sulfenyl compound - Thioether - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 36.15, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 18.07, Max Conc. mM: 50 Peso molecular 361.500 g/mol XLogP3 4.100 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 5 Exact Mass 361.081 Da Monoisotopic Mass 361.081 Da Topological Polar Surface Area 100.000 Ų Heavy Atom Count 24 Formal Charge 0 Complexity 473.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 1 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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