SRI-42127 - ≥99% , CAS No.2727872-68-4

CAS: 2727872-68-4 Cat. No.: S649484 Peso molecular: 348.40

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes

In Vitro

SRI-42127 (0.05-1 μM; 24 h) blocks HuR cytoplasmic translocation stimulated by LPS (1 μg/mL) in primary microglia. SRI-42127 (0.05-1 μM; 24 h) suppresses inflammatory cytokine and chemokine mRNA in activated Primary microglia cells (PMG). SRI-42127 (0.5 μM and 1 μM; 24 h) blocks glial-produced chemoattraction/migration signals for neutrophils and monocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRI-42127 (15 mg/kg; i.p.; single dose) suppresses HuR translocation and the activation of microglia in mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:HuR

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activat

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CN(C1CCOCC1)C2=NN3C(C=C2)=NC=C3C4=CC5=C(C=C4)C=NN5
• Peso molecular: 348.40