SRT 1720 Hydrochloride - ≥99% , CAS No.2060259-60-9

CAS: 2060259-60-9 Cat. No.: S648522 Peso molecular: 506.02

GRADE & PURITY ≥99%

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

SRT 1720 Hydrochloride is a selective and orally active activator of SIRT1 with an EC 50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3

In Vitro

SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRT 1720 (10, 30, 100 mg/kg, p.o.) treatment significantly reduces fasting blood glucose to near normal levels in Lep ob/ob mice . SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1. SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:SIRT1 0.10 μM (EC 50 ) SIRT1 0.16 μM (EC1.5) SIRT2 37 μM (EC1.5)

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

SRT 1720 hydrochloride is a selective and orally active activator of SIRT1 with an EC 50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C=CC=C3)C4=CN5C(CN6CCNCC6)=CSC5=N4.Cl
• Peso molecular: 506.02

Propiedades químicas y físicas

• Solubilidad: DMSO : 62.5 mg/mL (123.51 mM; Need ultrasonic) H2O : 15.7 mg/mL (31.03 mM; Need ultrasonic and warming)