STAT5-IN-2 - 10mM in DMSO , CAS No.2111834-61-6

CAS: 2111834-61-6 Cat. No.: S655921 Peso molecular: 397.51 PubChem CID: 137628635

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

STAT5-IN-2 is a STAT5 inhibitor,STAT5-IN-2 has potent antileukemic effect

In Vitro

STAT5-IN-2 has EC 50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively. STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC 50 values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively. STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells). STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: KG1a and MV-4-11 cell lines Concentration: 100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 48 hours Result: Inhibited cell growth in KG1a and MV-4-11 cell lines Apoptosis AnalysisCell Line: K562, KU812, KG1a and MV-4-11 cells Concentration: 10 µM Incubation Time: 48 hours Result: Significantly increased the number of apoptotic cells. Western Blot AnalysisCell Line: KG1a, MV-4-11 and KU812 cells Concentration: 10 µM Incubation Time: 24 hours Result: Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2.

IC50& Target:STAT5 9 μM (EC 50 , in K562 cells) STAT5 5 μM (EC 50 , in KU812 cells )

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• PubChem CID: 137628635
• Peso molecular: 397.51