Stepharine - ≥98% , CAS No.2810-21-1

CAS: 2810-21-1 Cat. No.: S649554 Peso molecular: 297.35 PubChem CID: 98455

COA

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Stepharine - ≥98% CAS No(2810-21-1) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥98%

Synonyms

HMS1607I01 | Spiro(2,5-cyclohexadien-1,7'(1'H)-cyclopent(ij)isoquinolin)-4-one, 2',3',8',8'a-tetrahydro-5,6-dimethoxy-, (R)- | 5',6'-dimethoxy-2',3',8',8a'-tetrahydro-1'h,4h-spiro[cyclohexa-2,5-diene-1,7'-cyclopenta[ij]isoquinolin]-4-one | E87202 | AKOS02

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging , anti-viral and anti-hypertensive effects.

In Vitro

Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells. Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation. Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stepharine (500 μg/kg) inhibited NeuN + cells loss and Iba-1 + cells increase in the MCAO ischemic cortex . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Middle cerebral artery occlusion (MCAO) rat model . Dosage: 500 μg/kg (20 μL). Administration: Intranasally injected into rats 1h after MCAO. Result: Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.

Form:Solid

Specifications

Sinónimos

HMS1607I01 | Spiro(2, 5-cyclohexadien-1, 7'(1'H)-cyclopent(ij)isoquinolin)-4-one, 2', 3', 8', 8'a-tetrahydro-5, 6-dimethoxy-, (R)- | 5', 6'-dimethoxy-2', 3', 8', 8a'-tetrahydro-1'h, 4h-spiro[cyclohexa-2, 5-diene-1, 7'-cyclopenta[ij]isoquinolin]-4-one | E87202 | AKOS02

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging , anti-viral and anti-hypertensive effects.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

Sonrisas canónicas	COC1=C(C2=C3C(CC24C=CC(=O)C=C4)NCCC3=C1)OC
IUPAC Name	10,11-dimethoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one
InChIKey	OGJKMZVUJJYWKO-UHFFFAOYSA-N
INCHI	1S/C18H19NO3/c1-21-14-9-11-5-8-19-13-10-18(6-3-12(20)4-7-18)16(15(11)13)17(14)22-2/h3-4,6-7,9,13,19H,5,8,10H2,1-2H3
Isómeros SMILES	COC1=C(C2=C3C(CC24C=CC(=O)C=C4)NCCC3=C1)OC
CAS alternativo	2810-21-1
PubChem CID	98455
Número NSC	135069
Términos de entrada MeSH	stepharine;stepharine monohydrochloride;stepharine tosylate
Peso molecular	297.35

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Clase Proaporphines

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Clase	Proaporphines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Proaporphines
Alternative Parents	Tetrahydroisoquinolines Indanes Anisoles Aralkylamines Alkyl aryl ethers Cyclic ketones Dialkylamines Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Proaporphine - Tetrahydroisoquinoline - Indane - Anisole - Alkyl aryl ether - Aralkylamine - Benzenoid - Ketone - Cyclic ketone - Secondary aliphatic amine - Ether - Secondary amine - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Amine - Organic nitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as proaporphines. These are benzylisoquinoline derivatives characterized by the presence of a spirocyclohexane ring that can occur in various oxidation levels, from cyclohexadienone to cyclohexanol.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

A498 (42825 Activities)

Solubilidad	DMSO : 25 mg/mL (84.08 mM; Need ultrasonic)
Peso molecular	297.300 g/mol
XLogP3	2.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	297.136 Da
Monoisotopic Mass	297.136 Da
Topological Polar Surface Area	47.600 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	510.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1