STF-62247 - 10mM in DMSO , CAS No.315702-99-9

CAS: 315702-99-9 Cat. No.: S408141 Fórmula: C₁₅H₁₃N₃S Peso molecular: 267.35 Número EC: 631-141-1 PubChem CID: 704473

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that inducesautophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to
In vitro

In vitro, STF-62247 shows cytotoxicity and tumor growth inhibitory activity against wild-type VHL and VHL-deficient renal cell carcinoma (RCC) in a HIF-independent manner with IC50 of 16 μM and 0.625 μM, respectively. Moreover, STF-62247 also leads to cell death by increasing acidification and inducing autophagy in VHL-deficient cells. ^[1] STF-62247 specifically induces macroautophagy and enhances the fusion of autophagosome and lysosomes to form autolysosomes by interfering with Golgi-endoplasmic reticulum transport in cells that have lost VHL . ^[2] A recent study shows that induction of autophagy by STF-62247 increases sensitivity of RCC under hypoxic conditions to radiation in a VHL-dependent manner. ^[3]

In vivo

In vivo mouse model, STF-62247 at a dose of 8 mg/kg by intraperitoneal injection significantly reduces tumor growth of VHL-deficient SN12C tumor cells. ^[1]
Cell Data

cell lines：

Concentrations：', 'Concentrations': '

0 to 40 μM

Incubation Time：

Powder Purity:

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly red

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Isómeros SMILES: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• WGK Alemania: 2
• PubChem CID: 704473
• Peso molecular: 267.35

Propiedades químicas y físicas

• Índice de refracción: 1.67
• Punto de ebullición (°C): 444.82° C
• Punto de fusión (°C): 174.66°C

Referencias

1. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang.  (2023)  Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy.  Small,      [PMID:36932938] [10.1002/smll.202207898]

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 315702-99-9, the molecular formula is C15H13N3S, and the molecular weight is 267.35 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.