Succinimidyl PEG NHS, mPEG-NHS - MW 350 Da

Cat. No.: S164327

GRADE & PURITY MW 350 Da

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH₂) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Specifications

Especificaciones y pureza

MW 350 Da

Mecanismos bioquímicos y fisiológicos

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

• Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-f

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Propiedades químicas y físicas

• Solubilidad: Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents
• Sensibilidad: air & moisture sensitive

Referencias

1. Jue Hou, Hanxiao Bao, Yu Wang, Qiaomei Zhou, Jiayi Chen, Guohua Pan, Guoqiao Xu, Jinguo Zhang, Guping Tang, Hongzhen Bai.  (2024)  A Hybrid Alloying Nanozyme-Glutathione Inhibitor Co-Delivery System Initiates a Dual-Disruption on Cancer Redox Homeostasis.  Small,      [PMID:39468865] [10.1002/smll.202407555]